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B4SD14 (AROE_PELPB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:Ppha_2066
OrganismPelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1) [Complete proteome] [HAMAP]
Taxonomic identifier324925 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Pelodictyon

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

shikimate 3-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Shikimate dehydrogenase HAMAP MF_00222
PRO_1000100128

Regions

Nucleotide binding130 – 1345NADP By similarity

Sites

Active site701Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
B4SD14 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 9E1B7DA5EA2A3CF0

FASTA28330,466
        10         20         30         40         50         60 
MTKSTKILGL IGRAVDYSYS PLIHNTACRL LGLSYHYTVF NIADPSMIPD ALRGAKALGI 

        70         80         90        100        110        120 
AGFNVTIPYK KSVVPFLDAL SAEAASIQAV NTIVNEGGKL TGHNTDIAGF AAPLLPYRES 

       130        140        150        160        170        180 
IRGKTLSIFG AGGAALAAIE AFIRFFSPKE ILLFVRNPEK ASLLLEESGH DKSAPVRILC 

       190        200        210        220        230        240 
SDNPEIIREC RVIVNATPIG TRGNNDSPLP LDRELLHPGQ IVYDMVYNPL DTPLLLAAQK 

       250        260        270        280 
AGAATISGIE MLIGQAEHSF TLWTGMQMPV KAVKESLLQE IQQ

« Hide

References

[1]"Complete sequence of Pelodictyon phaeoclathratiforme BU-1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 5477 / BU-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001110 Genomic DNA. Translation: ACF44273.1.
RefSeqYP_002018890.1. NC_011060.1.

3D structure databases

ProteinModelPortalB4SD14.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4SD14.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6462819.
GenomeReviewsGene locus Ppha_2066 in contig CP001110_GR.
KEGGpph:Ppha_2066.
PATRIC22904868. VBIPelPha134556_2206.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG553408.
OMALGIAGFN.
ProtClustDBCLSK637945.

Family and domain databases

HAMAPMF_00222. Shikimate_DH_AroE.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00014.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. AroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_PELPB
AccessionPrimary (citable) accession number: B4SD14
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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