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B4SB96

- GCSPB_PELPB

UniProt

B4SB96 - GCSPB_PELPB

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPPHA324925:GHBF-190-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Ppha_0179
OrganismiPelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Taxonomic identifieri324925 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
ProteomesiUP000002724: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi324925.Ppha_0179.

Structurei

3D structure databases

ProteinModelPortaliB4SB96.
SMRiB4SB96. Positions 4-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiKPVMHEF.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B4SB96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MREKLIFELS RKGRKGYSLS GNELPEQPLE NIIPSKYLRT TPAELPEVAE
60 70 80 90 100
SEVVRHFVRL SNLNYHVDKN MYPLGSCTMK YNPKINDYTC DLPGFSALHP
110 120 130 140 150
LQPGETTQGA LQLMFELAEM LREIAGMAAV TLQPAAGAHG ELTGILLIKK
160 170 180 190 200
YHESIGSKRH KLLVVDSAHG TNPASAALAG YDIISVKGNA DGRTDLDDLR
210 220 230 240 250
SKLDGDVAAL MLTNPNTIGL FETEILAISK MVHDNGSLLY MDGANMNALL
260 270 280 290 300
GITRPGDMGF DVVHYNLHKT FAAPHGGGGP GSGPVGVSEK LIPFLLVPVI
310 320 330 340 350
VKEGTTYKLS YDRPESIGRM MNFYGNFAVL VRAYTYIRML GPDGLRRVSE
360 370 380 390 400
NAIINANYLL SLLLESYDLP YPKPVMHEFC LSGDRQKKAH GVKTLDIAKR
410 420 430 440 450
LLDYGFHAPT IYFPLIVSEA LMIEPTETES KETLDVFAQA LLSIADEAAN
460 470 480
NPALVTSAPV TTPVKRLDDA MASRQLNICC SL
Length:482
Mass (Da):52,734
Last modified:September 23, 2008 - v1
Checksum:iFB92B9F264D0EBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001110 Genomic DNA. Translation: ACF42517.1.
RefSeqiYP_002017134.1. NC_011060.1.

Genome annotation databases

EnsemblBacteriaiACF42517; ACF42517; Ppha_0179.
GeneIDi6462296.
KEGGipph:Ppha_0179.
PATRICi22900782. VBIPelPha134556_0188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001110 Genomic DNA. Translation: ACF42517.1 .
RefSeqi YP_002017134.1. NC_011060.1.

3D structure databases

ProteinModelPortali B4SB96.
SMRi B4SB96. Positions 4-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324925.Ppha_0179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF42517 ; ACF42517 ; Ppha_0179 .
GeneIDi 6462296.
KEGGi pph:Ppha_0179.
PATRICi 22900782. VBIPelPha134556_0188.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi KPVMHEF.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PPHA324925:GHBF-190-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pelodictyon phaeoclathratiforme BU-1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5477 / BU-1.

Entry informationi

Entry nameiGCSPB_PELPB
AccessioniPrimary (citable) accession number: B4SB96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3