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Protein

Catalase-peroxidase

Gene

katG

Organism
Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei94Transition state stabilizerUniRule annotation1
Active sitei98Proton acceptorUniRule annotation1
Metal bindingi261Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPPHA324925:G1GCE-104-MONOMER

Protein family/group databases

PeroxiBasei2535 PphCP01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Ppha_0100
OrganismiPelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Taxonomic identifieri324925 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
Proteomesi
  • UP000002724 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548571 – 732Catalase-peroxidaseAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97 ↔ 220Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-246)UniRule annotation
Cross-linki220 ↔ 246Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB4SAT7

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi324925.Ppha_0100

Structurei

3D structure databases

ProteinModelPortaliB4SAT7
SMRiB4SAT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

B4SAT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQGKCPVT GRTAVNPVTT GGMSNRDWWP NQLHLDMLHQ HSSLTNPMGE
60 70 80 90 100
EFRYKEEFKK LDLKSVKKDL YALMTDSQEW WPADYGHYGG LFIRMAWHSA
110 120 130 140 150
GTYRTSDGRG GGGTGNQRFA PLNSWPDNAN LDKARRLLWP IKQKYGRKLS
160 170 180 190 200
WADLMILAGN CALESMGFKT FGFGGGRVDI WEPEEDIYWG KEVEWLGSNR
210 220 230 240 250
YSGERDLENP LAAVQMGLIY VNPEGPDGNP DPVAAGRDIR ETFARMAMND
260 270 280 290 300
EETVALVAGG HTFGKCHGVG DPKLIGPEPE AAEIEEQGLG WKSGYGSGKG
310 320 330 340 350
DETMTSGLEG AWTPDPIHWD MGYLGMLFKY EWELTKSPAG AWQWKPKDVA
360 370 380 390 400
EEDLAPAAHD PSKRVPTMMT TADLAMRMDP LYGPIARRYY EHPEQFADAF
410 420 430 440 450
ARAWFKLTHR DMGPRSRYLG AEVPAEELIW QDPVPAVDHE LIGEGKIKEL
460 470 480 490 500
KKRILASGLS IPELLSTAWA SASTFRSSDK RGGANGSRIR LSPQKEWEVN
510 520 530 540 550
QPEQLQRVLG KLEEIRNAFN GEQSGGKQVS LADLIVLGGC AAVEEAARRA
560 570 580 590 600
GNDVTVPFIP GRTDASQEQT DVESFAVLEP LADGFRNYTK RKYSVTPEEM
610 620 630 640 650
LIDRSQLLTL TATEMTVLLG GLRVLGVNFR QSPHGLFTNR PETLTNDFFV
660 670 680 690 700
NLLDMGTEWK PLSKEHETFE GRDRKTGEVR WSATRVDLIF GSNARLRAIA
710 720 730
EVYGSDDAQG KFVQDFVAAW NKVMNLDRFD LS
Length:732
Mass (Da):81,767
Last modified:September 23, 2008 - v1
Checksum:i6EB76293F950B982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001110 Genomic DNA Translation: ACF42456.1
RefSeqiWP_012506954.1, NC_011060.1

Genome annotation databases

EnsemblBacteriaiACF42456; ACF42456; Ppha_0100
KEGGipph:Ppha_0100

Similar proteinsi

Entry informationi

Entry nameiKATG_PELPB
AccessioniPrimary (citable) accession number: B4SAT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health