B4S9U8 (ARGB_PELPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Ppha_1381

Organism

Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1) [Complete proteome] [HAMAP]

Taxonomic identifier

324925 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Pelodictyon

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000092870
Regions
	Region	77 – 78	2	Substrate binding By similarity
Sites
	Binding site	99	1	Substrate By similarity
	Binding site	193	1	Substrate By similarity
	Site	42	1	Transition state stabilizer By similarity
	Site	252	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4S9U8 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: C890D603816CC91E	FASTA	304	32,583
	10 20 30 40 50 60 MDKLPCNELN QVRKAPHAAI GPVLIEALPY IRKFEGKTFV IKYGGAAMKD ACLKNSFAQN 70 80 90 100 110 120 VTLLRKVGIR IVLVHGGGDA ITKTAEKLGI TSRFLHGRRV TDKEMISVIQ MTLAGKVNQD 130 140 150 160 170 180 IVQLISEHGG KAVGVTGLDA DTIKALPHPN AETLGLVGEV EQINTAYIDL LCRAGLIPVI 190 200 210 220 230 240 APIGFDDKGN VYNINADDAA SSIAIALKAE KLIYVSDVEG IHVGERILKT ICKTEAADFI 250 260 270 280 290 300 EQGIISGGMI PKVLSAFKTL DSGVGKIHLI DGKATHSLLL EIFTHEGVGT QFIAEQDSDQ SQNR

References

[1]

"Complete sequence of Pelodictyon phaeoclathratiforme BU-1." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 5477 / BU-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001110 Genomic DNA. Translation: ACF43644.1.
RefSeq	YP_002018261.1. NC_011060.1.
3D structure databases
ProteinModelPortal	B4S9U8.
ModBase	Search...
Protein-protein interaction databases
STRING	B4S9U8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6463641.
GenomeReviews	Gene locus Ppha_1381 in contig CP001110_GR.
KEGG	pph:Ppha_1381.
PATRIC	22903340. VBIPelPha134556_1448.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG497643.
OMA	GGCLVDD.
ProtClustDB	PRK00942.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_PELPB

Accession

Primary (citable) accession number: B4S9U8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program