B4S9H4 (MSCL_PROA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	Paes_1626

Organism

Prosthecochloris aestuarii (strain DSM 271 / SK 413) [Complete proteome] [HAMAP]

Taxonomic identifier

290512 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Prosthecochloris

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_1000094913
Regions
	Transmembrane	10 – 30	21	Helical; Potential
	Transmembrane	76 – 96	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B4S9H4 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 462B635CEE710E11	FASTA	134	14,305
	10 20 30 40 50 60 MGFIQEFKDF AMRGNVVDLA VGIIIGGAFG KVVTALVDGV LMPPIGLLIG GVNFDQLAFE 70 80 90 100 110 120 LRAATAESAA VSLNYGAFLQ TIVDFVIIAF SIFVVIKALN SLKRKSEEAP KAPPVPSKEE 130 VLLGEIRDLL KERG

References

[1]

"Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 271 / SK 413.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001108 Genomic DNA. Translation: ACF46644.1.
RefSeq	YP_002016291.1. NC_011059.1.
3D structure databases
ProteinModelPortal	B4S9H4.
ModBase	Search...
Protein-protein interaction databases
STRING	B4S9H4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6459872.
GenomeReviews	Gene locus Paes_1626 in contig CP001108_GR.
KEGG	paa:Paes_1626.
PATRIC	23043128. VBIProAes37017_1732.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG727604.
OMA	IKATRCP.
ProtClustDB	CLSK2339382.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_PROA2

Accession

Primary (citable) accession number: B4S9H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program