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Protein

Malate dehydrogenase

Gene

mdh

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32NADUniRule annotation1
Binding sitei81SubstrateUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei94NADUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Active sitei174Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12NADUniRule annotation6
Nucleotide bindingi117 – 119NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciPAES290512:G1GCD-1632-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Paes_1603
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
Proteomesi
  • UP000002725 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001261451 – 310Malate dehydrogenaseAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi290512.Paes_1603

Structurei

3D structure databases

ProteinModelPortaliB4S9F1
SMRiB4S9F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.101 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

B4S9F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITVIGAGH VGATAAHRIA EMQLAKEVVL LDIVEGIPQG KALDMYESGP
60 70 80 90 100
IGLFDSKIYG TNDYQDTADS DIILITAGMA RKPGMSREDL LLKNATIVKE
110 120 130 140 150
VTDRIMQYSS NPIIIMVSNP LDIMTYVSYV RSKLPKERVI GMAGVLDSAR
160 170 180 190 200
FRSFIAEELN VSMKDINAFV LGGHGDSMVP VVKYTNIAGI PLTELLSQEK
210 220 230 240 250
IDSLVDRTRK GGAEIVNYLK DGSAYYAPAA SAVEMIDAIV HDRKRILPCS
260 270 280 290 300
TLVTGQYGMD NVFIGVPVKI GKNGIEEVLE INLDTAELEA LRQSASIVES
310
NCSNLADLLS
Length:310
Mass (Da):33,597
Last modified:September 23, 2008 - v1
Checksum:i2E426188255F8B0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA Translation: ACF46621.1
RefSeqiWP_012506154.1, NC_011059.1

Genome annotation databases

EnsemblBacteriaiACF46621; ACF46621; Paes_1603
KEGGipaa:Paes_1603

Similar proteinsi

Entry informationi

Entry nameiMDH_PROA2
AccessioniPrimary (citable) accession number: B4S9F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: February 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome