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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciPAES290512:G1GCD-1599-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Paes_1570
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000984271 – 317Methionyl-tRNA formyltransferaseAdd BLAST317

Proteomic databases

PRIDEiB4S9B8

Interactioni

Protein-protein interaction databases

STRINGi290512.Paes_1570

Structurei

3D structure databases

ProteinModelPortaliB4S9B8
SMRiB4S9B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 114Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

B4S9B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIIFMGTPD FAVPSLKAIA AMDGDFEVQL VVTGKDKPRR SKRSEPEPTP
60 70 80 90 100
VKKAARELGI PVMEVDDVKD ERFVDTVARY RPDVLVVAAF RILPPAVYEQ
110 120 130 140 150
ARLGAFNLHA SILPRYRGAA PVNWAIINGE RESGVTTFFL RKSVDTGNMI
160 170 180 190 200
LQEKTPVYPE ENAGELAARL AEIGAGAVVK TLELIRDGRV EPLLQNDTLA
210 220 230 240 250
TRAPKLSTEN TRIDWVQPVD ALCDFIRGLA PRPAAWAIFN HKKVKIFKAS
260 270 280 290 300
VADFHQPEAE EQSAIPGRIA VENNRLFVMG LDGWIEILSL QMEGKKVMQS
310
HEFCCGFRCD EECPVFS
Length:317
Mass (Da):35,272
Last modified:September 23, 2008 - v1
Checksum:i3D980A8546B82421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA Translation: ACF46588.1
RefSeqiWP_012506121.1, NC_011059.1

Genome annotation databases

EnsemblBacteriaiACF46588; ACF46588; Paes_1570
KEGGipaa:Paes_1570

Entry informationi

Entry nameiFMT_PROA2
AccessioniPrimary (citable) accession number: B4S9B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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