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Protein

Dihydrolipoyl dehydrogenase

Gene

Paes_1439

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciPAES290512:GHUT-1480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Paes_1439Imported
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)Imported
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
Proteomesi
  • UP000002725 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi290512.Paes_1439.

Structurei

3D structure databases

ProteinModelPortaliB4S8S2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 334323FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini354 – 462109Pyr_redox_dimInterPro annotationAdd
BLAST

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiEMAWFYA.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4S8S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEHDMHTQS DFDLAVIGSG PGGFEAAVRA ARKGLTVCVI ERGALGGVCV
60 70 80 90 100
NWGCIPTKAL LRSAEIFRLA GESSAFGLDI EASSIDLARA VKRSRKVVLL
110 120 130 140 150
ASKGVESALK KNKVTVFQGE ATFVDERTLR VSRDGQEDER LTAKHIIIAS
160 170 180 190 200
GARPREIPVL PVDGRHIMTS REALALKSAP ERMIVVGGGA IGLEMAWYYH
210 220 230 240 250
SAGTKVTVLE MLPRLLPLED KEVSEGLERL LKKAGISIHC EAAVVSASAG
260 270 280 290 300
DDGIVDAVVR MKDGSEQKMQ GECLLVAAGV VPNSGGLQLD AAGVILERGF
310 320 330 340 350
IATDAQCRTN VDHIYAIGDV RGGMQLAHKA SAEAVIAVES ITGGNPMPID
360 370 380 390 400
DAMVPRCVYV EPAVAAIGAS QEDAAAEGRE VMVGRAMFAA SGKASAYGFR
410 420 430 440 450
DGFVKLIFDA GSGVMIGGHV LGHGAVELIG ELSLAMRLGA TADQIASTIH
460
AHPTLSETVR EAAENAVVA
Length:469
Mass (Da):49,105
Last modified:September 23, 2008 - v1
Checksum:i439B15E308C5F493
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA. Translation: ACF46459.1.
RefSeqiWP_012505992.1. NC_011059.1.

Genome annotation databases

EnsemblBacteriaiACF46459; ACF46459; Paes_1439.
KEGGipaa:Paes_1439.
PATRICi23042712. VBIProAes37017_1527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA. Translation: ACF46459.1.
RefSeqiWP_012505992.1. NC_011059.1.

3D structure databases

ProteinModelPortaliB4S8S2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290512.Paes_1439.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF46459; ACF46459; Paes_1439.
KEGGipaa:Paes_1439.
PATRICi23042712. VBIProAes37017_1527.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiEMAWFYA.
OrthoDBiPOG091H0239.

Enzyme and pathway databases

BioCyciPAES290512:GHUT-1480-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4S8S2_PROA2
AccessioniPrimary (citable) accession number: B4S8S2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.