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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Paes_2266
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
Proteomesi
  • UP000002725 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21
Transmembranei170 – 190HelicalUniRule annotationAdd BLAST21
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Transmembranei238 – 258HelicalUniRule annotationAdd BLAST21
Transmembranei265 – 285HelicalUniRule annotationAdd BLAST21
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei345 – 365HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906571 – 368Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST368

Interactioni

Protein-protein interaction databases

STRINGi290512.Paes_2266.

Structurei

3D structure databases

SMRiB4S6R2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B4S6R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYLLQYIN DVFDPPGFGV VEYITFRASA AAITSLLITI FVGPRLIAYL
60 70 80 90 100
KRKYIEPIKE EAPPEHRKKK ELPTMGGTLI IFSILVSGLL WSRFNDPYVW
110 120 130 140 150
LILLAILWMG TIGFIDDYRK VVLKIKGGLA ARYKLIGQVS LGLVVGLYTW
160 170 180 190 200
YDPAFSVLQS QTTVPFFKNL TINYGIFYIP LVVFIITAVS NAVNLTDGLD
210 220 230 240 250
GLASGVSGIV VFALGGFAYL TGNTVYADYL NINYISGAGE VAILSMAIAM
260 270 280 290 300
SCVGFLWFNS HPAEIIMGDT GSLALGSAIA VIALLIKQEL LLPVLAGTFL
310 320 330 340 350
LETLSVSLQV AWFKFTRWRF GEGRRIFLMA PLHHHFQLKG WAEEKIVIRF
360
WIITLLFFLT SLMTLKLR
Length:368
Mass (Da):41,062
Last modified:September 23, 2008 - v1
Checksum:i8A49D8CE32EEF71C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA. Translation: ACF47267.1.
RefSeqiWP_012506797.1. NC_011059.1.

Genome annotation databases

EnsemblBacteriaiACF47267; ACF47267; Paes_2266.
KEGGipaa:Paes_2266.

Similar proteinsi

Entry informationi

Entry nameiMRAY_PROA2
AccessioniPrimary (citable) accession number: B4S6R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: June 7, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families