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B4S6L0

- PDXA_PROA2

UniProt

B4S6L0 - PDXA_PROA2

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei140 – 1401SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Metal bindingi172 – 1721Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi217 – 2171Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi271 – 2711Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei279 – 2791SubstrateUniRule annotation
    Binding sitei288 – 2881SubstrateUniRule annotation
    Binding sitei297 – 2971SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, NADP

    Enzyme and pathway databases

    BioCyciPAES290512:GHUT-742-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:Paes_0718
    OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
    Taxonomic identifieri290512 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
    ProteomesiUP000002725: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3383384-hydroxythreonine-4-phosphate dehydrogenasePRO_1000146492Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi290512.Paes_0718.

    Structurei

    3D structure databases

    ProteinModelPortaliB4S6L0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221591.
    KOiK00097.
    OMAiSIDIRTI.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4S6L0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTTAWTIGD IHGIGPEIIL KTFDESLRST GQPEEKPIVI GSAEALLYYS    50
    KRLGLSIDIR TIDAPEKAAA YPQGVLPVIS VGEPSSPLQP GTISAEAGRL 100
    SMLAIEKAAN LCLEGRCAAM VTAPIHKEAV ARAGYPHTGH TDFLADLCAT 150
    DNPTMLFRDP VSGLMVALAT IHVALHRVPE LIRSMDMSAF FSNLNRSLQS 200
    DFRIEQPRIA VLGLNPHASD GGVMGREEKE IILPCIDALA DRQNIEGPFA 250
    ADGFFGSGKY RNYDVTVAMY HDQGLLPFKV LAFDTGINVT LGLPLVRTSP 300
    DHGTSFDIAG QGRASHRSFS EAAKLAWEIA FNRLMEHS 338
    Length:338
    Mass (Da):36,521
    Last modified:September 23, 2008 - v1
    Checksum:iB625A431436286D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001108 Genomic DNA. Translation: ACF45765.1.
    RefSeqiWP_012505302.1. NC_011059.1.
    YP_002015412.1. NC_011059.1.

    Genome annotation databases

    EnsemblBacteriaiACF45765; ACF45765; Paes_0718.
    GeneIDi6459914.
    KEGGipaa:Paes_0718.
    PATRICi23041122. VBIProAes37017_0749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001108 Genomic DNA. Translation: ACF45765.1 .
    RefSeqi WP_012505302.1. NC_011059.1.
    YP_002015412.1. NC_011059.1.

    3D structure databases

    ProteinModelPortali B4S6L0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290512.Paes_0718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF45765 ; ACF45765 ; Paes_0718 .
    GeneIDi 6459914.
    KEGGi paa:Paes_0718.
    PATRICi 23041122. VBIProAes37017_0749.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221591.
    KOi K00097.
    OMAi SIDIRTI.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci PAES290512:GHUT-742-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 271 / SK 413.

    Entry informationi

    Entry nameiPDXA_PROA2
    AccessioniPrimary (citable) accession number: B4S6L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3