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Protein

NAD kinase

Gene

nadK

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorUniRule annotation1
Binding sitei148NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei167NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 67NADUniRule annotation2
Nucleotide bindingi137 – 138NADUniRule annotation2
Nucleotide bindingi178 – 183NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAES290512:G1GCD-2198-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Paes_2165
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
Proteomesi
  • UP000002725 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208771 – 285NAD kinaseAdd BLAST285

Proteomic databases

PRIDEiB4S665

Interactioni

Protein-protein interaction databases

STRINGi290512.Paes_2165

Structurei

3D structure databases

ProteinModelPortaliB4S665
SMRiB4S665
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B4S665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFAIVVNIN REDALELAQE LTSWLQERGL SYVLDSVSGE KTGIEPSMAM
60 70 80 90 100
EELNKDCDAF ISLGGDGTLL FTSHYSVTKP VIGINVGHLG FLAEFSKAEM
110 120 130 140 150
FEAVEQVLNG TYSIHVRSQL EAEVTMNGGL KHLTALNDVV IEKGAYPRIP
160 170 180 190 200
TFIIKLDDEL LSAYRADGII IATSTGSTAY SLSAGGPIIA PKSNVFVITP
210 220 230 240 250
ICPHMLTVRP IVISDDKTIQ ISVEAHGGEF PLNCDGHVSK MLLPGETIIV
260 270 280
RKSEQIINLV ENKNRRYCEI LRSKLLWGHE HQSGS
Length:285
Mass (Da):31,182
Last modified:September 23, 2008 - v1
Checksum:i14EEA6254E495B01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA Translation: ACF47167.1
RefSeqiWP_012506698.1, NC_011059.1

Genome annotation databases

EnsemblBacteriaiACF47167; ACF47167; Paes_2165
KEGGipaa:Paes_2165

Similar proteinsi

Entry informationi

Entry nameiNADK_PROA2
AccessioniPrimary (citable) accession number: B4S665
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health