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B4S5L2 (B4S5L2_PROA2) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224
Gene names
Name:pyrD HAMAP MF_00224
Ordered Locus Names:Paes_0553
OrganismProsthecochloris aestuarii (strain DSM 271 / SK 413) [Complete proteome] [HAMAP] EMBL ACF45609.1
Taxonomic identifier290512 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Prosthecochloris

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224

Catalytic activity

(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224

Cofactor

Binds 1 FMN per subunit By similarity. HAMAP MF_00224

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224

Subcellular location

Cytoplasm By similarity HAMAP MF_00224.

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Ontologies

Keywords
   Biological processPyrimidine biosynthesis HAMAP MF_00224
   Cellular componentCytoplasm HAMAP MF_00224
   LigandFMN HAMAP MF_00224
Flavoprotein HAMAP MF_00224
   Molecular functionOxidoreductase HAMAP MF_00224
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' pyrimidine base biosynthetic process

Inferred from electronic annotation. Source: InterPro

UMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: HAMAP

   Molecular functiondihydroorotate oxidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1351Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

Sequence LengthMass (Da)Tools
B4S5L2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 3449A93682509622

FASTA30933,008
        10         20         30         40         50         60 
MTQESRHTAV ALGRGLELRS PVLLASGTVS YGEELSKLTD LSRIGGLVTK AISPEPRIGN 

        70         80         90        100        110        120 
RPQRIAETPC GMVNAIGLAN VGLERFVAEK LPFLQNLDTA VIVNVAGKSI DDYVQVVQRI 

       130        140        150        160        170        180 
DEYDGIDGYE INLSCPNVKG ECMIMGVSST ATFEIISKLR SITNRHLMVK LTPNVTSISA 

       190        200        210        220        230        240 
IALAAEEAGA DSVSLINTLV GMAVDHKTRK PLLTNITGGL SGPAIKPVAL AKVWEVYNAV 

       250        260        270        280        290        300 
NIPIVGMGGI SNVEDAMEFL VTGARAIQIG TMNFVYPDIG QTIADKLEEY FSSPEQMTLE 


EYSGSLIVA

« Hide

References

[1]"Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 271 / SK 413.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001108 Genomic DNA. Translation: ACF45609.1.
RefSeqYP_002015256.1. NC_011059.1.

3D structure databases

ProteinModelPortalB4S5L2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4S5L2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6460019.
GenomeReviewsGene locus Paes_0553 in contig CP001108_GR.
KEGGpaa:Paes_0553.
PATRIC23040764. VBIProAes37017_0577.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG472415.
OMAVALRMVW.
ProtClustDBCLSK637846.

Family and domain databases

HAMAPMF_00224. DHO_dh_type1.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsTIGR01037. PyrD_sub1_fam. 1 hit.
PROSITEPS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4S5L2_PROA2
AccessionPrimary (citable) accession number: B4S5L2
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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