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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciPAES290512:G1GCD-535-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Paes_0535
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
Proteomesi
  • UP000002725 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324861 – 444Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST444

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi290512.Paes_0535

Structurei

3D structure databases

ProteinModelPortaliB4S5J4
SMRiB4S5J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEM Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B4S5J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIANTDDD RRSMLQAIGV GSFEELIPDI PSEFCLKEAL SLFPSMSEME
60 70 80 90 100
VASLLDRLAS ANRTSPDYVS FIGGGAYDHY IPAALKTIVS RSEFYTAYTP
110 120 130 140 150
YQAEVSQGTL QAIYEYQSMI CRLYGMSVAN ASLYDGATAM AEAVSMAMNV
160 170 180 190 200
TGRSTVLVAG KIHPNTSAVL KTFIEAGGKA SVVQNVLTDG VCDIAALESR
210 220 230 240 250
MSDQIAAVIV QQPNFYGCLE DVEAIGALAR SHGALFIVSA DPVSLGLLNA
260 270 280 290 300
PGRYGADIAV GEGQPLGSAL NFGGPYLGIF AVAEKYVRKI PGRLVGMTKD
310 320 330 340 350
RDGEDGFILT LQTREQHIRR EKATSNICTN QALNALQAVV YLSLMGKDGL
360 370 380 390 400
CQVAEHCLQK AHYLADKIAD LPGYSLRFAG PFFREFVVNT PVDASVVVNT
410 420 430 440
MMEKGFFAGY DLGIHDDSGL LIAVTEKRSR AEMDSFVENL GAIS
Length:444
Mass (Da):47,735
Last modified:September 23, 2008 - v1
Checksum:iCD1088EC46CA40D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA Translation: ACF45591.1
RefSeqiWP_012505128.1, NC_011059.1

Genome annotation databases

EnsemblBacteriaiACF45591; ACF45591; Paes_0535
KEGGipaa:Paes_0535

Similar proteinsi

Entry informationi

Entry nameiGCSPA_PROA2
AccessioniPrimary (citable) accession number: B4S5J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health