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B4S5J4

- GCSPA_PROA2

UniProt

B4S5J4 - GCSPA_PROA2

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciPAES290512:GHUT-552-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Paes_0535
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
ProteomesiUP000002725: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132486Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi290512.Paes_0535.

Structurei

3D structure databases

ProteinModelPortaliB4S5J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiYVRKIPG.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B4S5J4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFIANTDDD RRSMLQAIGV GSFEELIPDI PSEFCLKEAL SLFPSMSEME
60 70 80 90 100
VASLLDRLAS ANRTSPDYVS FIGGGAYDHY IPAALKTIVS RSEFYTAYTP
110 120 130 140 150
YQAEVSQGTL QAIYEYQSMI CRLYGMSVAN ASLYDGATAM AEAVSMAMNV
160 170 180 190 200
TGRSTVLVAG KIHPNTSAVL KTFIEAGGKA SVVQNVLTDG VCDIAALESR
210 220 230 240 250
MSDQIAAVIV QQPNFYGCLE DVEAIGALAR SHGALFIVSA DPVSLGLLNA
260 270 280 290 300
PGRYGADIAV GEGQPLGSAL NFGGPYLGIF AVAEKYVRKI PGRLVGMTKD
310 320 330 340 350
RDGEDGFILT LQTREQHIRR EKATSNICTN QALNALQAVV YLSLMGKDGL
360 370 380 390 400
CQVAEHCLQK AHYLADKIAD LPGYSLRFAG PFFREFVVNT PVDASVVVNT
410 420 430 440
MMEKGFFAGY DLGIHDDSGL LIAVTEKRSR AEMDSFVENL GAIS
Length:444
Mass (Da):47,735
Last modified:September 23, 2008 - v1
Checksum:iCD1088EC46CA40D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001108 Genomic DNA. Translation: ACF45591.1.
RefSeqiYP_002015238.1. NC_011059.1.

Genome annotation databases

EnsemblBacteriaiACF45591; ACF45591; Paes_0535.
GeneIDi6459922.
KEGGipaa:Paes_0535.
PATRICi23040724. VBIProAes37017_0557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001108 Genomic DNA. Translation: ACF45591.1 .
RefSeqi YP_002015238.1. NC_011059.1.

3D structure databases

ProteinModelPortali B4S5J4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290512.Paes_0535.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF45591 ; ACF45591 ; Paes_0535 .
GeneIDi 6459922.
KEGGi paa:Paes_0535.
PATRICi 23040724. VBIProAes37017_0557.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi YVRKIPG.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci PAES290512:GHUT-552-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 271 / SK 413.

Entry informationi

Entry nameiGCSPA_PROA2
AccessioniPrimary (citable) accession number: B4S5J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3