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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi505MagnesiumUniRule annotation1
Metal bindingi511MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Paes_0506
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
Proteomesi
  • UP000002725 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003819121 – 734Polyribonucleotide nucleotidyltransferaseAdd BLAST734

Interactioni

Protein-protein interaction databases

STRINGi290512.Paes_0506.

Structurei

3D structure databases

ProteinModelPortaliB4S5G5.
SMRiB4S5G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini572 – 631KHUniRule annotationAdd BLAST60
Domaini641 – 715S1 motifUniRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.230.70. 2 hits.
3.30.300.20. 1 hit.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR015946. KH_dom-like_a/b.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

B4S5G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMFIRKEID LGSGKTLSIE TGKMAKQADG SAIVRLNDTM VLATVVSSKT
60 70 80 90 100
PPSPNQSFFP LQVEYREKYS AAGKFPGGFF KREGRPSEKE ILSARLIDRA
110 120 130 140 150
LRPLFPDGYY QDTQIIISVI SSDQINDADV LGGVAASAAI MVSDIPFQNS
160 170 180 190 200
MSEVRVGRVN GEYIVNPNIN ELRDSDIDIS IGGTENTICM LEGEMDEISE
210 220 230 240 250
AEMLEAIRFG HEAIKKICAL QNEIAAEVGK TARTFSAAKA PDNLRQSIAE
260 270 280 290 300
ICSNELKELA YMPLCKEERA EKTAEIYKNA KAQTLQRYQQ EITPEVIAAE
310 320 330 340 350
PEKALYLNEQ IIGDAIHSIE KQVMREMILD DAKRLDGRRL DEVRPISIEL
360 370 380 390 400
GLIPRAHGSA LFTRGETQAL VTLTLGTKKD AQMIDTLTDD ADKRFMLHYN
410 420 430 440 450
FPPFSVGETG RVGGTSRREI GHGNLAERAI RKVAPAESAF PYTIRIVSDI
460 470 480 490 500
LESNGSSSMA SVCGGALAAM DGGVPLRKPV SGIAMGLIKE GDRYAVLSDI
510 520 530 540 550
LGNEDHLGDM DFKVAGTADG ITACQMDIKI DGLDYHILEQ ALEQALHGRL
560 570 580 590 600
HILDKMNEAI QEPRTEIGKY APKLTTIQIP VDAIGMVIGK GGETIRSITE
610 620 630 640 650
ETGAEINIED DGTVTIASAS GEGASAALET IKLLISKPEV GTVYSGKVRD
660 670 680 690 700
IREDLGAFVE FLPKTDGLVH ISEISNERVA KVSDHLKPGD KVKVKLVDVR
710 720 730
KDPRTGKTRF ALSIKALAEK SADNGASDKA EANR
Length:734
Mass (Da):79,779
Last modified:September 23, 2008 - v1
Checksum:i299C6850683628FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA. Translation: ACF45562.1.

Genome annotation databases

EnsemblBacteriaiACF45562; ACF45562; Paes_0506.
KEGGipaa:Paes_0506.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPNP_PROA2
AccessioniPrimary (citable) accession number: B4S5G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 23, 2008
Last modified: June 7, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families