ID SYL_PROA2 Reviewed; 806 AA. AC B4S5G4; DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 1. DT 27-MAR-2024, entry version 91. DE RecName: Full=Leucine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00049}; DE EC=6.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00049}; DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00049}; DE Short=LeuRS {ECO:0000255|HAMAP-Rule:MF_00049}; GN Name=leuS {ECO:0000255|HAMAP-Rule:MF_00049}; GN OrderedLocusNames=Paes_0505; OS Prosthecochloris aestuarii (strain DSM 271 / SK 413). OC Bacteria; Chlorobiota; Chlorobiia; Chlorobiales; Chlorobiaceae; OC Prosthecochloris. OX NCBI_TaxID=290512; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 271 / SK 413; RG US DOE Joint Genome Institute; RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., RA Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., RA Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F., Overmann J., RA Bryant D.A., Richardson P.; RT "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."; RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl- CC tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA- CC COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427, CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4; CC Evidence={ECO:0000255|HAMAP-Rule:MF_00049}; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00049}. CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family. CC {ECO:0000255|HAMAP-Rule:MF_00049}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001108; ACF45561.1; -; Genomic_DNA. DR RefSeq; WP_012505098.1; NC_011059.1. DR AlphaFoldDB; B4S5G4; -. DR SMR; B4S5G4; -. DR STRING; 290512.Paes_0505; -. DR KEGG; paa:Paes_0505; -. DR eggNOG; COG0495; Bacteria. DR HOGENOM; CLU_004427_0_0_10; -. DR Proteomes; UP000002725; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:UniProtKB-UniRule. DR CDD; cd07958; Anticodon_Ia_Leu_BEm; 1. DR CDD; cd00812; LeuRS_core; 1. DR Gene3D; 3.10.20.590; -; 1. DR Gene3D; 3.40.50.620; HUPs; 2. DR HAMAP; MF_00049_B; Leu_tRNA_synth_B; 1. DR InterPro; IPR002300; aa-tRNA-synth_Ia. DR InterPro; IPR002302; Leu-tRNA-ligase. DR InterPro; IPR025709; Leu_tRNA-synth_edit. DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd. DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth. DR InterPro; IPR014729; Rossmann-like_a/b/a_fold. DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd. DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit. DR NCBIfam; TIGR00396; leuS_bact; 1. DR PANTHER; PTHR43740:SF2; LEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1. DR PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1. DR Pfam; PF08264; Anticodon_1; 1. DR Pfam; PF00133; tRNA-synt_1; 1. DR Pfam; PF13603; tRNA-synt_1_2; 1. DR Pfam; PF09334; tRNA-synt_1g; 1. DR PRINTS; PR00985; TRNASYNTHLEU. DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1. DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1. DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1. PE 3: Inferred from homology; KW Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase; KW Nucleotide-binding; Protein biosynthesis; Reference proteome. FT CHAIN 1..806 FT /note="Leucine--tRNA ligase" FT /id="PRO_1000091344" FT MOTIF 40..51 FT /note="'HIGH' region" FT MOTIF 576..580 FT /note="'KMSKS' region" FT BINDING 579 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00049" SQ SEQUENCE 806 AA; 92200 MW; 080A408174850D76 CRC64; MRYEFSTIEQ KWQKYWADNQ TFLTDDNPDK PKYYVLDMFP YPSGTGLHVG HLEGYTATDI IARYKRSRGF NVLHPMGWDA FGLPAEQFAI KTGTHPTTTT QKNVSSFRQT LQNMGFSYDW SREINTTDPN YFRWTQWIFL QLLDKGLAYM SEVDVNWCED LRVVLANEEV DEKIAAGHTV VRKPLRQWVL KITAYAERLL GDLDELDWPE NVKQMQRNWI GRSEGVEIDF ELPCHRQKLT VYTTRPDTLF GASYLVISPE HPLAEKLATA PQLVELKNYI REAKLKTELE RTGLQKEKTG VFTGSYAINP ANGEALPVWV SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF GLPIIEVIQS PHDVQDEVFE GKESICVNSS NNEISLDGLD FTSAFKRMAD WIESSGKGRR KINYKLRDWI FSRQRYWGEP IPVKHYDDGS LRPETDLPLT LPEVEAYHPS TTGESPLANI EDWLFGQDEH GAFRRETNTM PQWAGSCWYY LRFIDPSNQQ QLVDPDKERY WMNVDLYIGG AEHAVLHLLY ARFWHKVLYD LGVVSTKEPF QKLFNQGMIL GEDNEKMSKS RGNVIPADHV MQSYGADAVR LYEMFLGPLE QVKPWNTNGI EGISRFLSRV WRIVYPEQEG PAMLTDTPLD DALTRRMHKT IKKVTEDTEH LKFNTAIAEM MVFVNELHKA GCRNRKALET LLLLLAPYAP HICEELWQAA GNNEPIARAP FPVFDPALAE DNELTIAVQV NGKLRGTFLA PAGLSKEAMI AGAREIESVK KFLEGMTIIK EIAVPGKLVN FAVKPL //