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B4S5G4

- SYL_PROA2

UniProt

B4S5G4 - SYL_PROA2

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Protein
Leucine--tRNA ligase
Gene
leuS, Paes_0505
Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAES290512:GHUT-522-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Paes_0505
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
ProteomesiUP000002725: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligaseUniRule annotation
PRO_1000091344Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290512.Paes_0505.

Structurei

3D structure databases

ProteinModelPortaliB4S5G4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B4S5G4-1 [UniParc]FASTAAdd to Basket

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MRYEFSTIEQ KWQKYWADNQ TFLTDDNPDK PKYYVLDMFP YPSGTGLHVG    50
HLEGYTATDI IARYKRSRGF NVLHPMGWDA FGLPAEQFAI KTGTHPTTTT 100
QKNVSSFRQT LQNMGFSYDW SREINTTDPN YFRWTQWIFL QLLDKGLAYM 150
SEVDVNWCED LRVVLANEEV DEKIAAGHTV VRKPLRQWVL KITAYAERLL 200
GDLDELDWPE NVKQMQRNWI GRSEGVEIDF ELPCHRQKLT VYTTRPDTLF 250
GASYLVISPE HPLAEKLATA PQLVELKNYI REAKLKTELE RTGLQKEKTG 300
VFTGSYAINP ANGEALPVWV SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF 350
GLPIIEVIQS PHDVQDEVFE GKESICVNSS NNEISLDGLD FTSAFKRMAD 400
WIESSGKGRR KINYKLRDWI FSRQRYWGEP IPVKHYDDGS LRPETDLPLT 450
LPEVEAYHPS TTGESPLANI EDWLFGQDEH GAFRRETNTM PQWAGSCWYY 500
LRFIDPSNQQ QLVDPDKERY WMNVDLYIGG AEHAVLHLLY ARFWHKVLYD 550
LGVVSTKEPF QKLFNQGMIL GEDNEKMSKS RGNVIPADHV MQSYGADAVR 600
LYEMFLGPLE QVKPWNTNGI EGISRFLSRV WRIVYPEQEG PAMLTDTPLD 650
DALTRRMHKT IKKVTEDTEH LKFNTAIAEM MVFVNELHKA GCRNRKALET 700
LLLLLAPYAP HICEELWQAA GNNEPIARAP FPVFDPALAE DNELTIAVQV 750
NGKLRGTFLA PAGLSKEAMI AGAREIESVK KFLEGMTIIK EIAVPGKLVN 800
FAVKPL 806
Length:806
Mass (Da):92,200
Last modified:September 23, 2008 - v1
Checksum:i080A408174850D76
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001108 Genomic DNA. Translation: ACF45561.1.
RefSeqiWP_012505098.1. NC_011059.1.
YP_002015208.1. NC_011059.1.

Genome annotation databases

EnsemblBacteriaiACF45561; ACF45561; Paes_0505.
GeneIDi6459499.
KEGGipaa:Paes_0505.
PATRICi23040666. VBIProAes37017_0528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001108 Genomic DNA. Translation: ACF45561.1 .
RefSeqi WP_012505098.1. NC_011059.1.
YP_002015208.1. NC_011059.1.

3D structure databases

ProteinModelPortali B4S5G4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290512.Paes_0505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF45561 ; ACF45561 ; Paes_0505 .
GeneIDi 6459499.
KEGGi paa:Paes_0505.
PATRICi 23040666. VBIProAes37017_0528.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PAES290512:GHUT-522-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 271 / SK 413.

Entry informationi

Entry nameiSYL_PROA2
AccessioniPrimary (citable) accession number: B4S5G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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