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B4S5G4

- SYL_PROA2

UniProt

B4S5G4 - SYL_PROA2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPAES290512:GHUT-522-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Paes_0505
    OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
    Taxonomic identifieri290512 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
    ProteomesiUP000002725: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 806806Leucine--tRNA ligasePRO_1000091344Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290512.Paes_0505.

    Structurei

    3D structure databases

    ProteinModelPortaliB4S5G4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4S5G4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYEFSTIEQ KWQKYWADNQ TFLTDDNPDK PKYYVLDMFP YPSGTGLHVG    50
    HLEGYTATDI IARYKRSRGF NVLHPMGWDA FGLPAEQFAI KTGTHPTTTT 100
    QKNVSSFRQT LQNMGFSYDW SREINTTDPN YFRWTQWIFL QLLDKGLAYM 150
    SEVDVNWCED LRVVLANEEV DEKIAAGHTV VRKPLRQWVL KITAYAERLL 200
    GDLDELDWPE NVKQMQRNWI GRSEGVEIDF ELPCHRQKLT VYTTRPDTLF 250
    GASYLVISPE HPLAEKLATA PQLVELKNYI REAKLKTELE RTGLQKEKTG 300
    VFTGSYAINP ANGEALPVWV SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF 350
    GLPIIEVIQS PHDVQDEVFE GKESICVNSS NNEISLDGLD FTSAFKRMAD 400
    WIESSGKGRR KINYKLRDWI FSRQRYWGEP IPVKHYDDGS LRPETDLPLT 450
    LPEVEAYHPS TTGESPLANI EDWLFGQDEH GAFRRETNTM PQWAGSCWYY 500
    LRFIDPSNQQ QLVDPDKERY WMNVDLYIGG AEHAVLHLLY ARFWHKVLYD 550
    LGVVSTKEPF QKLFNQGMIL GEDNEKMSKS RGNVIPADHV MQSYGADAVR 600
    LYEMFLGPLE QVKPWNTNGI EGISRFLSRV WRIVYPEQEG PAMLTDTPLD 650
    DALTRRMHKT IKKVTEDTEH LKFNTAIAEM MVFVNELHKA GCRNRKALET 700
    LLLLLAPYAP HICEELWQAA GNNEPIARAP FPVFDPALAE DNELTIAVQV 750
    NGKLRGTFLA PAGLSKEAMI AGAREIESVK KFLEGMTIIK EIAVPGKLVN 800
    FAVKPL 806
    Length:806
    Mass (Da):92,200
    Last modified:September 23, 2008 - v1
    Checksum:i080A408174850D76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001108 Genomic DNA. Translation: ACF45561.1.
    RefSeqiWP_012505098.1. NC_011059.1.
    YP_002015208.1. NC_011059.1.

    Genome annotation databases

    EnsemblBacteriaiACF45561; ACF45561; Paes_0505.
    GeneIDi6459499.
    KEGGipaa:Paes_0505.
    PATRICi23040666. VBIProAes37017_0528.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001108 Genomic DNA. Translation: ACF45561.1 .
    RefSeqi WP_012505098.1. NC_011059.1.
    YP_002015208.1. NC_011059.1.

    3D structure databases

    ProteinModelPortali B4S5G4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290512.Paes_0505.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF45561 ; ACF45561 ; Paes_0505 .
    GeneIDi 6459499.
    KEGGi paa:Paes_0505.
    PATRICi 23040666. VBIProAes37017_0528.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PAES290512:GHUT-522-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 271 / SK 413.

    Entry informationi

    Entry nameiSYL_PROA2
    AccessioniPrimary (citable) accession number: B4S5G4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3