B4S580 (B4S580_PROA2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387
Short name=UDP-N-acetylglucosamine acyltransferase HAMAP MF_00387
EC=2.3.1.129 HAMAP MF_00387

Gene names

Name:	lpxA HAMAP MF_00387
Ordered Locus Names:	Paes_2016

Organism

Prosthecochloris aestuarii (strain DSM 271 / SK 413) [Complete proteome] [HAMAP] EMBL ACF47026.1

Taxonomic identifier

290512 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Prosthecochloris

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP MF_00387

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00387 Lipid synthesis
Cellular component	Cytoplasm HAMAP MF_00387
Domain	Repeat HAMAP MF_00387
Molecular function	Acyltransferase HAMAP MF_00387 EMBL ACF47026.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4S580 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 99E7AFB6641410FE	FASTA	268	28,959
	10 20 30 40 50 60 MFMSSSMIHP TAIIGSGAEI GEGVRIGPYS VIEDDVQIGS NTEIGPHVQI ADGARIGESC 70 80 90 100 110 120 RIFAGAVLST VPQDLKFEGE KTSLHIGDRT VIRECVTLNR GTKASGKTVV GSDCLIMAYV 130 140 150 160 170 180 HAGHDCVIGN HVIIANSVQF GGHCQVEDYA VVGGLAGIHQ FVRIGRYAMV GGISRASLDV 190 200 210 220 230 240 PPFVMAGGHE KFRFEGLNIV GLKRRGFSSA QLDRIRAIYR ILFQSGMLLG NALDKVLTDC 250 260 EESPERDEIL AFFDTSSARR KYIRPYNS

References

[1]

"Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 271 / SK 413.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001108 Genomic DNA. Translation: ACF47026.1.
RefSeq	YP_002016673.1. NC_011059.1.
3D structure databases
ProteinModelPortal	B4S580.
ModBase	Search...
Protein-protein interaction databases
STRING	B4S580.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6459811.
GenomeReviews	Gene locus Paes_2016 in contig CP001108_GR.
KEGG	paa:Paes_2016.
PATRIC	23043960. VBIProAes37017_2145.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG659295.
OMA	REFCTFN.
ProtClustDB	PRK05289.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 3 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B4S580_PROA2

Accession

Primary (citable) accession number: B4S580

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)