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B4S4I2 (KDSB_PROA2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase
Gene names
Name:kdsB
Ordered Locus Names:Paes_1866
OrganismProsthecochloris aestuarii (strain DSM 271 / SK 413) [Complete proteome] [HAMAP]
Taxonomic identifier290512 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Prosthecochloris

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP MF_00057

Catalytic activity

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP MF_00057

Pathway

Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP MF_00057

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00057

Subcellular location

Cytoplasm Potential HAMAP MF_00057.

Sequence similarities

Belongs to the KdsB family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-deoxy-manno-octulosonate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2492493-deoxy-manno-octulosonate cytidylyltransferase HAMAP MF_00057
PRO_1000091886

Sequences

Sequence LengthMass (Da)Tools
B4S4I2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 4867E52DE283782C

FASTA24927,833
        10         20         30         40         50         60 
MPPINIVILI PARLNSSRLP NKMLADIEGA PLIVRTWQQA QQSSLTRQVV IATDSEEIAG 

        70         80         90        100        110        120 
VMKACGADVV MTSPDARCGT ERIAEAAENI DADVFVNLQG DEPLIDPGNI DLVIKPFLQE 

       130        140        150        160        170        180 
NPPDCSTLVY RLLAEDYAAL HDPNIVKVVM DSQSNALYFS RSPLPYQRET YAATRCFRHI 

       190        200        210        220        230        240 
GIYAFRAGVL RMFSEHGPSM LEEAESLEQL RLVENGYSIR CVETDVDMPG VNTHEDLELV 


RRLYRSRRS

« Hide

References

[1]"Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 271 / SK 413.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001108 Genomic DNA. Translation: ACF46878.1.
RefSeqYP_002016525.1. NC_011059.1.

3D structure databases

ProteinModelPortalB4S4I2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4S4I2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6460149.
GenomeReviewsGene locus Paes_1866 in contig CP001108_GR.
KEGGpaa:Paes_1866.
PATRIC23043642. VBIProAes37017_1987.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG637773.
OMAFSRAPLP.
ProtClustDBPRK05450.

Family and domain databases

HAMAPMF_00057. CMP-KDO_synth.
[Tree]
InterProIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
[Graphical view]
KOK00979.
PANTHERPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamPF02348. CTP_transf_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00466. KdsB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSB_PROA2
AccessionPrimary (citable) accession number: B4S4I2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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