Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B4S3H9

- PUR9_PROA2

UniProt

B4S3H9 - PUR9_PROA2

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciPAES290512:GHUT-1745-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Paes_1700
    OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
    Taxonomic identifieri290512 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
    ProteomesiUP000002725: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Bifunctional purine biosynthesis protein PurHPRO_1000096081Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290512.Paes_1700.

    Structurei

    3D structure databases

    ProteinModelPortaliB4S3H9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiIRASSKN.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4S3H9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDPVIKRAL VSVSDKTGIV DFCRELGAMG VEIFSTGGTL RILQESGIEA    50
    ASISTITGFP EIMDGRVKTL HPKIHGGLLA VRDNEDHVGQ AKANGIEFID 100
    MVVVNLYPFE ATVAKPDVTF EEAIENIDIG GPSMLRSAAK NNESVTVVTD 150
    SADYATVLDE MRSNNGATRR ETRLTLARKV FELTSRYDRA IADYLIGAEE 200
    SGETEAPAAI SVKLEKELDM RYGENPHQSA GFYRLVDGQG SRCFDDFFDK 250
    LHGKELSYNN MLDIAAATGL VEEFRGEDPA VVIIKHTNPC GVAQAGTLVD 300
    AYRKAFSTDT QSPFGGIIAF NVPLDMETAL AVDEIFTEIL IAPAYEDGVL 350
    DMLMKKKNRR LVLQKKALLQ EVMEYKSTQF GMLVQDRDSK IVSREDLKVV 400
    TKRQPDEQEL DDMMFAWKIA KHVKSNTIVY VKNGQTIGVG AGQMSRIDSA 450
    KIARSKAAEA GLDIKGSAVA SDAFFPFADG LLAAAEAGAT SVIQPGGSIR 500
    DDEVIAAADE NNLAMVFTSM RHFKH 525
    Length:525
    Mass (Da):57,196
    Last modified:September 23, 2008 - v1
    Checksum:i1299B42DBDC30A96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001108 Genomic DNA. Translation: ACF46718.1.
    RefSeqiWP_012506251.1. NC_011059.1.
    YP_002016365.1. NC_011059.1.

    Genome annotation databases

    EnsemblBacteriaiACF46718; ACF46718; Paes_1700.
    GeneIDi6459862.
    KEGGipaa:Paes_1700.
    PATRICi23043290. VBIProAes37017_1813.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001108 Genomic DNA. Translation: ACF46718.1 .
    RefSeqi WP_012506251.1. NC_011059.1.
    YP_002016365.1. NC_011059.1.

    3D structure databases

    ProteinModelPortali B4S3H9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290512.Paes_1700.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF46718 ; ACF46718 ; Paes_1700 .
    GeneIDi 6459862.
    KEGGi paa:Paes_1700.
    PATRICi 23043290. VBIProAes37017_1813.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi IRASSKN.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci PAES290512:GHUT-1745-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 271 / SK 413.

    Entry informationi

    Entry nameiPUR9_PROA2
    AccessioniPrimary (citable) accession number: B4S3H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3