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B4S3H1

- UPPP_PROA2

UniProt

B4S3H1 - UPPP_PROA2

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciPAES290512:GHUT-1737-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Paes_1692
    OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)
    Taxonomic identifieri290512 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
    ProteomesiUP000002725: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Undecaprenyl-diphosphatasePRO_1000197390Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290512.Paes_1692.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei85 – 10521HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei158 – 17821HelicalUniRule annotationAdd
    BLAST
    Transmembranei193 – 21321HelicalUniRule annotationAdd
    BLAST
    Transmembranei231 – 25121HelicalUniRule annotationAdd
    BLAST
    Transmembranei258 – 27821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiMEQINIG.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4S3H1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLFEAIILG IAQGLTEFLP ISSTAHLRIV PALAGWQDPG AAFTAIVQIG    50
    TLIAVLIYFF RDIVTISGAV IKGLMNASPL GTPDAKMGWM IAAGTIPIVV 100
    FGLLFKTEIE TSLRSLYWIS AALITLAIIL SLAEWLIKKR IAKGIEPKSM 150
    SDIRWKEALI IGLVQSIALI PGSSRSGVTI TGGLFMNLSR ETAARFSFLL 200
    SLPAVFAAGI YQLYKSWDSL MASTNDLVNL IVATLVAGIV GYASIAFLIT 250
    FLKQHSTAVF IIYRIALGLT ILALIATGNV QA 282
    Length:282
    Mass (Da):30,157
    Last modified:September 23, 2008 - v1
    Checksum:iF699CAC632511579
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001108 Genomic DNA. Translation: ACF46710.1.
    RefSeqiWP_012506243.1. NC_011059.1.
    YP_002016357.1. NC_011059.1.

    Genome annotation databases

    EnsemblBacteriaiACF46710; ACF46710; Paes_1692.
    GeneIDi6459950.
    KEGGipaa:Paes_1692.
    PATRICi23043274. VBIProAes37017_1805.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001108 Genomic DNA. Translation: ACF46710.1 .
    RefSeqi WP_012506243.1. NC_011059.1.
    YP_002016357.1. NC_011059.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290512.Paes_1692.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF46710 ; ACF46710 ; Paes_1692 .
    GeneIDi 6459950.
    KEGGi paa:Paes_1692.
    PATRICi 23043274. VBIProAes37017_1805.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi MEQINIG.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci PAES290512:GHUT-1737-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 271 / SK 413.

    Entry informationi

    Entry nameiUPPP_PROA2
    AccessioniPrimary (citable) accession number: B4S3H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3