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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Paes_1677

Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei253 – 2531Critical for catalysisUniRule annotation
Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
Sitei418 – 4181Critical for catalysisUniRule annotation
Binding sitei545 – 5451SubstrateUniRule annotation
Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPAES290512:GHUT-1722-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Paes_1677Imported
OrganismiProsthecochloris aestuarii (strain DSM 271 / SK 413)Imported
Taxonomic identifieri290512 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeProsthecochloris
ProteomesiUP000002725 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi290512.Paes_1677.

Structurei

3D structure databases

ProteinModelPortaliB4S3F6.
SMRiB4S3F6. Positions 3-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

B4S3F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIIYTKID EAPALATYSL LPIIQAFTSG TGVEVETRDI SLAGRIIANF
60 70 80 90 100
PDNLTPEQQI PDYLSELGEL AKTKEANIIK LPNISASIPQ LQAAIKELQS
110 120 130 140 150
KGYNVPDYPE EPKNDAEKEI KVRYAKVLGS AVNPVLREGN SDRRAAASVK
160 170 180 190 200
QYAQNNPHRL RAWESGSKAS VAYMESGDFY ETEKSATMNG ADSVRIEYVD
210 220 230 240 250
GDGNVTVLKD SLSLLDGEVI DTSIMNVRKL RDFYAAQIER SKNDDMLLSL
260 270 280 290 300
HLKATMMKVS DPIMFGHAVL VFYKDVFDKH GDTFKALGVN VNNGLGDVYA
310 320 330 340 350
KIQSLPEDKR AEIEADIQAV YPSRPALAMV DSDKGITNLH VPNDIIIDAS
360 370 380 390 400
MPVVIRDGGK MWGPDGELHD TTAMIPDRCY ATMYQEMIED CQKNGAYDVS
410 420 430 440 450
TMGSVSNVGL MAQKAEEYGS HDKTFEAPGD GVIRVVDGSG KAMLEQVVET
460 470 480 490 500
GDIYRMCQVK DAPIRDWVKL AVNRAKATGV PAVFWLDKER AHHVQLIEKV
510 520 530 540 550
TAYLKEHDTE GLDIRIMSPV EAMRFSLERI RAGKDTISVT GNVLRDYLTD
560 570 580 590 600
LFPILELGTS AKMLSIVPLM NGGGLFETGA GGSAPKHVQQ FLKEGHLRWD
610 620 630 640 650
SLGEMLALGV SLEHLAAAFK NDKAQVLADT VDQAVGQYLE NRKSPSRKVN
660 670 680 690 700
EIDNRGSHYY FALYWAQALA AQDKDQELKA KFAGIAESMA ASEAAIIDEL
710 720 730
NAAQGSAVDV DGYFMPDDEK ASQAMRPSAT LNAIIDALK
Length:739
Mass (Da):81,028
Last modified:September 22, 2008 - v1
Checksum:iD26FC43C6D4E343F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA. Translation: ACF46695.1.
RefSeqiYP_002016342.1. NC_011059.1.

Genome annotation databases

EnsemblBacteriaiACF46695; ACF46695; Paes_1677.
KEGGipaa:Paes_1677.
PATRICi23043238. VBIProAes37017_1787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001108 Genomic DNA. Translation: ACF46695.1.
RefSeqiYP_002016342.1. NC_011059.1.

3D structure databases

ProteinModelPortaliB4S3F6.
SMRiB4S3F6. Positions 3-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290512.Paes_1677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF46695; ACF46695; Paes_1677.
KEGGipaa:Paes_1677.
PATRICi23043238. VBIProAes37017_1787.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciPAES290512:GHUT-1722-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 271 / SK 413Imported.

Entry informationi

Entry nameiB4S3F6_PROA2
AccessioniPrimary (citable) accession number: B4S3F6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2008
Last sequence update: September 22, 2008
Last modified: March 31, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.