Skip Header

Contribute Send feedback
Read comments (?) or add your own

B4S1X4 (ILVC_ALTMD) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:MADE_1020145
OrganismAlteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP]
Taxonomic identifier314275 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000190903

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
B4S1X4 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 56CF5E0475A22504

FASTA49254,009
        10         20         30         40         50         60 
MANYFNTLSL RQQLDQLGRC RFMARDEFAD GCQFLKGKKV VIVGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LDVSYALRQA AIDEQRDSYK RASSNGFTVG TYQQLIPEAD VVYNLTPDKQ HASVVEAVMP 

       130        140        150        160        170        180 
LMKKGATLGY SHGFNIVEEG QQIRSDITVI MCAPKSPGSE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPEGKGWDQ AKALASATGG DRAGVLESSF VAEVKSDLMG EQTILCGMQQ VAAVLAFEKM 

       250        260        270        280        290        300 
VDDGIDPGYA GALIQYGLEA ITEALKIGGV TNMMDRLSNP AKVKAFELSE QLTDLLRPLF 

       310        320        330        340        350        360 
EKHQDDIISG EFSRTMMEDW ANGDANLLKW REETGETAFE NAPAYEGEIS EQEFFDHGIL 

       370        380        390        400        410        420 
LVAMIKCGVE VAFDVMVEAG ILPESAYYES LHETPLISNT IARKRLYEMN VVISDTAEYG 

       430        440        450        460        470        480 
NYLFANAAIP ILREKFMPTI DTTVIGKGLT AASNQVENKR LVEINEAIRS HGVESVGKTL 

       490 
RGYMTDMKAI VV 

« Hide

References

[1]"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
ISME J. 2:1194-1212(2008) [PubMed: 18670397] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17117 / Deep ecotype.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001103 Genomic DNA. Translation: AEB00152.1.
RefSeqYP_004429149.1. NC_011138.2.

3D structure databases

ProteinModelPortalB4S1X4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4S1X4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10559369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG297205.
OMAEKHMDDI.
ProtClustDBPRK05225.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_ALTMD
AccessionPrimary (citable) accession number: B4S1X4
Secondary accession number(s): F2GCG5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families