Reviewed, UniProtKB/Swiss-Prot B4S0H8 (ARGC_ALTMD)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	MADE_00532

Organism

Alteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP]

Taxonomic identifier

314275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Alteromonas

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000096712
Sites
	Active site	155	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4S0H8-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: C000F197F49D0D1A	FASTA	337	35,969
	10 20 30 40 50 60 MYSVSIIGAS GYTGAQLVQL VLQHPKLELA GTYVSENSND ANKSIAELHG NLAHVNATLT 70 80 90 100 110 120 PISDTALSEM ANGVDFIFLA TPHEASHDWM PILSSGKAKV LDLSGAFRIK DTAVFEQFYG 130 140 150 160 170 180 FPHTQTQSLA QAVYGLAEWH EAQIASADVI AVPGCYPTAS LSALKPLAHN GLLDESVRPV 190 200 210 220 230 240 INAVSGVSGA GRKASLTTSF FEVSLQAYGV LGHRHTPEIE AYLGTPVIFT PHLGNFKRGI 250 260 270 280 290 300 LATVTVKVKA GTTSAQLEKA YTDAYADKPI VRLRKSFPKI DDVAHTPFVD LHWKLDEASG 310 320 330 YAVVTAAIDN VMKGAASQAI QCLNIMTKQP IETGLVL

References

[1]

"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter." Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F. ISME J. 2:1194-1212(2008) [PubMed: 18670397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001103 Genomic DNA. Translation: ACG64850.1.
RefSeq	YP_002124844.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6778064.
GenomeReviews	Gene locus MADE_00532 in contig CP001103_GR.
KEGG	amc:MADE_00532.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VCRIAVH.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_ALTMD

Accession

Primary (citable) accession number: B4S0H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)