B4S0H7 (ARGB_ALTMD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	MADE_1002660

Organism

Alteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP]

Taxonomic identifier

314275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Alteromonas

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000118329
Regions
	Region	43 – 44	2	Substrate binding By similarity
Sites
	Binding site	65	1	Substrate By similarity
	Binding site	157	1	Substrate By similarity
	Site	9	1	Transition state stabilizer By similarity
	Site	216	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4S0H7 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: BBCE9BF6BFD81F30	FASTA	267	27,086
	10 20 30 40 50 60 MSVSPIVIKV GGALLDDAAA MTRLFLSVKD VQATRPVVVV HGGGPLVETL MASLGLKSTK 70 80 90 100 110 120 IDGLRVTPDE HMPYICGALA GSANKQLCAA ALASGLTPVG LSLLDGNMVV CEPLADQYGA 130 140 150 160 170 180 VGVPSTADAA FLKSVLAQST LPIISSIGSS PQGRLLNVNA DQAATVIAEL LNAELLLLSN 190 200 210 220 230 240 VDGVLDGNKA LISALNANSI AQYASEGVIT DGMKVKVDAA LASAESLSRP VYIASWAADI 250 260 TDILNKTTGT QIVPTTLAAE NGNAGEI

References

[1]

"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter." Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F. ISME J. 2:1194-1212(2008) [PubMed: 18670397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17117 / Deep ecotype.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001103 Genomic DNA. Translation: AEA96681.1.
RefSeq	YP_004425679.1. NC_011138.2.
3D structure databases
ProteinModelPortal	B4S0H7.
ModBase	Search...
Protein-protein interaction databases
STRING	B4S0H7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10555876.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG497643.
OMA	GGCLVDD.
ProtClustDB	PRK00942.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ALTMD

Accession

Primary (citable) accession number: B4S0H7
Secondary accession number(s): F2G7A1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	September 23, 2008
Last modified:	October 19, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program