Reviewed, UniProtKB/Swiss-Prot B4S0H4 (ARLY_ALTMD)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	MADE_00528

Organism

Alteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP]

Taxonomic identifier

314275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Alteromonas

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Argininosuccinate lyase HAMAP MF_00006		PRO_1000089064

Sequences

	Sequence		Length	Mass (Da)
	B4S0H4-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 1472B831E3D68D25	FASTA	460	50,400
	10 20 30 40 50 60 MALWGGRFES GASSMFKQVN DSLPFDQVMA SQDIQGSISW SRALQKAGVL TADEQAQLEG 70 80 90 100 110 120 ALSELKAQAD AGELDFNASS EEDIHSFVEA ALIEKLGDIG RKLHTGRSRN DQVATDFRLW 130 140 150 160 170 180 VREHIASLRA DVLGVIKSLL NAASRHQEAI IPGYTHLQRA QPIHFAHWCL AYVEMLKRDL 190 200 210 220 230 240 SRLDDLKVRM NQCPLGSGAL AGTTFPVDRH AIAEELGFDS PCLNSLDAVS DRDFVLELLF 250 260 270 280 290 300 VASTSMMHLS RLAEDMIFYN SGEAGFLQLG DSVTSGSSLM PQKKNPDALE LMRGKCGRVF 310 320 330 340 350 360 GALQALLVTM KGLPLAYNKD MQEDKEGAID TVNQWHICLC IASEVLDSLQ LNEERCRVAA 370 380 390 400 410 420 AQGFSNATEL ADYLVGKGVP FRTGHDIAGR VVLQAIDKGC AIEDLPLSDL QAISDKIEDD 430 440 450 460 VYPVLQLEYG VNQRNILGGT SKETVTKALY QELENLDKQG

References

[1]

"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter." Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F. ISME J. 2:1194-1212(2008) [PubMed: 18670397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001103 Genomic DNA. Translation: ACG64846.1.
RefSeq	YP_002124840.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6778141.
GenomeReviews	Gene locus MADE_00528 in contig CP001103_GR.
KEGG	amc:MADE_00528.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ALTMD

Accession

Primary (citable) accession number: B4S0H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)