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B4RZX7

- PUR5_ALTMD

UniProt

B4RZX7 - PUR5_ALTMD

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAMAC314275:GHA7-2202-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:MADE_1010880
    OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
    Taxonomic identifieri314275 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
    ProteomesiUP000001870: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000192989Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314275.MADE_02148.

    Structurei

    3D structure databases

    ProteinModelPortaliB4RZX7.
    SMRiB4RZX7. Positions 6-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    KOiK01933.
    OMAiEFEMYRT.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4RZX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSENKTSLSY KDAGVDIDAG NQLVERIKSV TKKTHRPEVK GNLGGFGALC    50
    ELPTKYKKPL LVSGTDGVGT KLRVAMDANR HDGVGIDLVA MCVNDLIVQG 100
    AEPLFFLDYY ATGKLDVDVA ASVVTGIGAG CEQAGCALIG GETAEMPGMY 150
    HDGDYDIAGF CVGVVEADNV IDGTNVKPGQ KLIALGSSGP HSNGYSLVRK 200
    IIEVSGADVN AELNGKPIID QLLEPTRIYV KSVLALLEEV QVSAISHITG 250
    GGFWENIPRV LPEDAKVVID EKSWEWPAVF SWLQENGNVT RHEMYRTFNC 300
    GVGLVIVVDD ADTEQAVNIL KQHGENAWVI GDIASKDGEE QVEINA 346
    Length:346
    Mass (Da):37,011
    Last modified:September 23, 2008 - v1
    Checksum:iC74E2D1D9BAC0547
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001103 Genomic DNA. Translation: AEA98314.1.
    RefSeqiYP_004427312.1. NC_011138.3.

    Genome annotation databases

    EnsemblBacteriaiAEA98314; AEA98314; MADE_1010880.
    GeneIDi10557523.
    KEGGiamc:MADE_1010880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001103 Genomic DNA. Translation: AEA98314.1 .
    RefSeqi YP_004427312.1. NC_011138.3.

    3D structure databases

    ProteinModelPortali B4RZX7.
    SMRi B4RZX7. Positions 6-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314275.MADE_02148.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA98314 ; AEA98314 ; MADE_1010880 .
    GeneIDi 10557523.
    KEGGi amc:MADE_1010880.

    Phylogenomic databases

    eggNOGi COG0150.
    KOi K01933.
    OMAi EFEMYRT.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci AMAC314275:GHA7-2202-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
      Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
      ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17117 / Deep ecotype.

    Entry informationi

    Entry nameiPUR5_ALTMD
    AccessioniPrimary (citable) accession number: B4RZX7
    Secondary accession number(s): F2G3E2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3