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B4RZX7

- PUR5_ALTMD

UniProt

B4RZX7 - PUR5_ALTMD

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMAC314275:GHA7-2202-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:MADE_1010880
OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
Taxonomic identifieri314275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000001870: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000192989Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314275.MADE_02148.

Structurei

3D structure databases

ProteinModelPortaliB4RZX7.
SMRiB4RZX7. Positions 6-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiEFEMYRT.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RZX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSENKTSLSY KDAGVDIDAG NQLVERIKSV TKKTHRPEVK GNLGGFGALC
60 70 80 90 100
ELPTKYKKPL LVSGTDGVGT KLRVAMDANR HDGVGIDLVA MCVNDLIVQG
110 120 130 140 150
AEPLFFLDYY ATGKLDVDVA ASVVTGIGAG CEQAGCALIG GETAEMPGMY
160 170 180 190 200
HDGDYDIAGF CVGVVEADNV IDGTNVKPGQ KLIALGSSGP HSNGYSLVRK
210 220 230 240 250
IIEVSGADVN AELNGKPIID QLLEPTRIYV KSVLALLEEV QVSAISHITG
260 270 280 290 300
GGFWENIPRV LPEDAKVVID EKSWEWPAVF SWLQENGNVT RHEMYRTFNC
310 320 330 340
GVGLVIVVDD ADTEQAVNIL KQHGENAWVI GDIASKDGEE QVEINA
Length:346
Mass (Da):37,011
Last modified:September 23, 2008 - v1
Checksum:iC74E2D1D9BAC0547
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA98314.1.
RefSeqiWP_012518637.1. NC_011138.3.
YP_004427312.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA98314; AEA98314; MADE_1010880.
GeneIDi10557523.
KEGGiamc:MADE_1010880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA98314.1 .
RefSeqi WP_012518637.1. NC_011138.3.
YP_004427312.1. NC_011138.3.

3D structure databases

ProteinModelPortali B4RZX7.
SMRi B4RZX7. Positions 6-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314275.MADE_02148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA98314 ; AEA98314 ; MADE_1010880 .
GeneIDi 10557523.
KEGGi amc:MADE_1010880.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi EFEMYRT.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci AMAC314275:GHA7-2202-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
    Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
    ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17117 / Deep ecotype.

Entry informationi

Entry nameiPUR5_ALTMD
AccessioniPrimary (citable) accession number: B4RZX7
Secondary accession number(s): F2G3E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3