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B4RYN9

- PANC_ALTMD

UniProt

B4RYN9 - PANC_ALTMD

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Protein
Pantothenate synthetase
Gene
panC1, MADE_1017490
panC2, MADE_1018445
Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donor By similarity
Binding sitei61 – 611Beta-alanine By similarity
Binding sitei61 – 611Pantoate By similarity
Binding sitei155 – 1551Pantoate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATP By similarity
Nucleotide bindingi149 – 1524ATP By similarity
Nucleotide bindingi186 – 1894ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMAC314275:GHA7-3530-MONOMER.
AMAC314275:GHA7-3721-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC1
Ordered Locus Names:MADE_1017490
AND
Name:panC2
Ordered Locus Names:MADE_1018445
OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
Taxonomic identifieri314275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000001870: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Pantothenate synthetaseUniRule annotation
PRO_1000097028Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi314275.MADE_03551.

Structurei

3D structure databases

ProteinModelPortaliB4RYN9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
KOiK01918.
OMAiHAGHMEL.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RYN9-1 [UniParc]FASTAAdd to Basket

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MKVIDSISTL RQTVNAWRRN GESVGFVPTM GNLHDGHLKL VKKAKAHNDN    50
VVVSIFVNPM QFGANEDLDA YPRTIEEDKA KLISVGADAV FLPSVAEMYP 100
AGLDAQTFVE VPGISDSHCG ASRPGHFRGV ATVVTKLFNM VQPDDAFFGE 150
KDFQQLQVIR ALARDLSMAV TIHGVPTERE ASGLAMSSRN GYLSKEEKAT 200
ASAIYEEMQR VKAGIEGGNI DFSELEDAMV TNLEAKGFKK DYCQVVNAST 250
FKAATANDKE LVLLVAMFMG KTRLIDNLQI TR 282
Length:282
Mass (Da):30,833
Last modified:September 23, 2008 - v1
Checksum:iAC943C3604B879E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001103 Genomic DNA. Translation: AEA99622.1.
CP001103 Genomic DNA. Translation: AEA99813.1.
RefSeqiWP_012519844.1. NC_011138.3.
YP_004428811.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA99813; AEA99813; MADE_1018445.
GeneIDi10559035.
KEGGiamc:MADE_1018445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001103 Genomic DNA. Translation: AEA99622.1 .
CP001103 Genomic DNA. Translation: AEA99813.1 .
RefSeqi WP_012519844.1. NC_011138.3.
YP_004428811.1. NC_011138.3.

3D structure databases

ProteinModelPortali B4RYN9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 314275.MADE_03551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA99813 ; AEA99813 ; MADE_1018445 .
GeneIDi 10559035.
KEGGi amc:MADE_1018445.

Phylogenomic databases

eggNOGi COG0414.
KOi K01918.
OMAi HAGHMEL.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci AMAC314275:GHA7-3530-MONOMER.
AMAC314275:GHA7-3721-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
    Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
    ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17117 / Deep ecotype.

Entry informationi

Entry nameiPANC_ALTMD
AccessioniPrimary (citable) accession number: B4RYN9
Secondary accession number(s): F2G683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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