B4RY28 (UPPP_ALTMD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	MADE_1003810

Organism

Alteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP]

Taxonomic identifier

314275 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Alteromonas › Alteromonas macleodii

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000134678
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B4RY28 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 79E23AEFC3833E49	FASTA	266	28,991
	10 20 30 40 50 60 MTLFEIIILA IIQGVTEFLP ISSSGHLLLP AELLGWVSQG LAFDVAVHVG SLLAVMIYFR 70 80 90 100 110 120 QEIGQMTVAW VTQGFSKQQS TDSKLAWYVI VGTIPAVIIG FLMKGWIEEN ARTALVIAGT 130 140 150 160 170 180 TIIFGLLLWY ADATAKREQE LEGLTLKQAI YIGLAQVLAL IPGTSRSGIT MTAGLMLGLK 190 200 210 220 230 240 REACARFSFL LSIPVILGAG LLATLDLLSA NEAVDWYALL YGAAFSFVSA YLCIYLFLSW 250 260 IARIGMLPFV IYRLALGAVL LWFVFA

References

[1]

"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter." Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F. ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17117 / Deep ecotype.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001103 Genomic DNA. Translation: AEA96910.1.
RefSeq	YP_004425908.1. NC_011138.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	314275.MADE_03448.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEA96910; AEA96910; MADE_1003810.
GeneID	10556106.
KEGG	amc:MADE_1003810.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
KO	K06153.
OMA	ITITTAR.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	AMAC314275:GHA7-778-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_ALTMD

Accession

Primary (citable) accession number: B4RY28
Secondary accession number(s): F2G9Y3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program