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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi377 – 384GTPUniRule annotation8
Nucleotide bindingi423 – 427GTPUniRule annotation5
Nucleotide bindingi477 – 480GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:MADE_1008920
OrganismiAlteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Taxonomic identifieri1774373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
Proteomesi
  • UP000001870 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000937551 – 868Translation initiation factor IF-2Add BLAST868

Proteomic databases

PRIDEiB4RXT8.

Interactioni

Protein-protein interaction databases

STRINGi314275.MADE_1008920.

Structurei

3D structure databases

ProteinModelPortaliB4RXT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini368 – 537tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni377 – 384G1By similarity8
Regioni402 – 406G2By similarity5
Regioni423 – 426G3By similarity4
Regioni477 – 480G4By similarity4
Regioni513 – 515G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
KOiK02519.
OMAiEVIKQMM.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4RXT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVSIEKLA SDIGTTVDRL VGQFKDAGIS KSAGEQVNED EKQKLLDHLS
60 70 80 90 100
KQHGSAAEPT RMTLKRKTTS TLSVGKSKEV KVEVRKKRTY VKRSDIEEQQ
110 120 130 140 150
RQAEEEAKRL EEEARLKREA EEKAAAEAKK AAEEKARKAQ EAKKAAEEER
160 170 180 190 200
VRRAEQAKKE AEARKKDEPE LTEAEKAEAE AARQEEERLR KAQEEEAQKK
210 220 230 240 250
LEEDAKKAAD EARKLAEENE RRWKEEEERR KKAEAEEVHL HSNRYAQEAE
260 270 280 290 300
DEEDMQVERS SRRRRKSKKN AGEHLKQGFN KPAAPVERVV KLGATITVGE
310 320 330 340 350
LASKLAIKSN EVIKTMMKMG EMATINQVLD QDTAVLVIEE MGHKYELVND
360 370 380 390 400
NALEDELLAD GTDGEKTSRA PVVTIMGHVD HGKTSLLDYI RRAKVADGEA
410 420 430 440 450
GGITQHIGAY KVQTDNGEIT FLDTPGHAAF TAMRARGATA TDIVILVVAA
460 470 480 490 500
DDGVMPQTKE AVQHARAAGV PLIVAVNKMD KETADPDRVK TELSQLEVIS
510 520 530 540 550
EEWGGEHQFC NVSAKTGMGV DELLEAIVLQ SELLDLQAVA EGPGRGIVIE
560 570 580 590 600
SRLDKGRGPV ASVLVQEGQL RAGDILLCGE EYGRVRAMRD ENGKDMKLAG
610 620 630 640 650
PSTPVEVLGL SGVPVAGEDA AVVKDERKAR EVAAKRHQKK RELKLARQQK
660 670 680 690 700
AKLENMFANM ESGDVSELNI VLKADVQGSV EAISESLIKL STSEVKVNIV
710 720 730 740 750
GSGVGGITET DATLAAASGA IVLGFNVRAD ATARRVLEAE EIDLRYYSVI
760 770 780 790 800
YNLIDEVKAA MSGMLAPEFK QEIIGLAEVR DVFKSPKLGA IAGCMVTEGN
810 820 830 840 850
VKRSNPIRVL RDNVVIYEGE LESLRRFKDD VQDVRNGMEC GIGVKNYNDV
860
KVGDQIEVFE IVEVKREI
Length:868
Mass (Da):95,580
Last modified:September 23, 2008 - v1
Checksum:i32AA374822B8D3FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA97922.1.
RefSeqiWP_012518253.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA97922; AEA97922; MADE_1008920.
GeneIDi10557126.
KEGGiamc:MADE_1008920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA97922.1.
RefSeqiWP_012518253.1. NC_011138.3.

3D structure databases

ProteinModelPortaliB4RXT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314275.MADE_1008920.

Proteomic databases

PRIDEiB4RXT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA97922; AEA97922; MADE_1008920.
GeneIDi10557126.
KEGGiamc:MADE_1008920.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
KOiK02519.
OMAiEVIKQMM.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_ALTMD
AccessioniPrimary (citable) accession number: B4RXT8
Secondary accession number(s): F2GAC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.