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B4RXT8

- IF2_ALTMD

UniProt

B4RXT8 - IF2_ALTMD

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi377 – 3848GTPUniRule annotation
    Nucleotide bindingi423 – 4275GTPUniRule annotation
    Nucleotide bindingi477 – 4804GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAMAC314275:GHA7-1804-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:MADE_1008920
    OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
    Taxonomic identifieri314275 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
    ProteomesiUP000001870: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 868868Translation initiation factor IF-2PRO_1000093755Add
    BLAST

    Proteomic databases

    PRIDEiB4RXT8.

    Interactioni

    Protein-protein interaction databases

    STRINGi314275.MADE_01760.

    Structurei

    3D structure databases

    ProteinModelPortaliB4RXT8.
    SMRiB4RXT8. Positions 2-50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini368 – 537170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni377 – 3848G1By similarity
    Regioni402 – 4065G2By similarity
    Regioni423 – 4264G3By similarity
    Regioni477 – 4804G4By similarity
    Regioni513 – 5153G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    KOiK02519.
    OMAiDATGKTR.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4RXT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADVSIEKLA SDIGTTVDRL VGQFKDAGIS KSAGEQVNED EKQKLLDHLS    50
    KQHGSAAEPT RMTLKRKTTS TLSVGKSKEV KVEVRKKRTY VKRSDIEEQQ 100
    RQAEEEAKRL EEEARLKREA EEKAAAEAKK AAEEKARKAQ EAKKAAEEER 150
    VRRAEQAKKE AEARKKDEPE LTEAEKAEAE AARQEEERLR KAQEEEAQKK 200
    LEEDAKKAAD EARKLAEENE RRWKEEEERR KKAEAEEVHL HSNRYAQEAE 250
    DEEDMQVERS SRRRRKSKKN AGEHLKQGFN KPAAPVERVV KLGATITVGE 300
    LASKLAIKSN EVIKTMMKMG EMATINQVLD QDTAVLVIEE MGHKYELVND 350
    NALEDELLAD GTDGEKTSRA PVVTIMGHVD HGKTSLLDYI RRAKVADGEA 400
    GGITQHIGAY KVQTDNGEIT FLDTPGHAAF TAMRARGATA TDIVILVVAA 450
    DDGVMPQTKE AVQHARAAGV PLIVAVNKMD KETADPDRVK TELSQLEVIS 500
    EEWGGEHQFC NVSAKTGMGV DELLEAIVLQ SELLDLQAVA EGPGRGIVIE 550
    SRLDKGRGPV ASVLVQEGQL RAGDILLCGE EYGRVRAMRD ENGKDMKLAG 600
    PSTPVEVLGL SGVPVAGEDA AVVKDERKAR EVAAKRHQKK RELKLARQQK 650
    AKLENMFANM ESGDVSELNI VLKADVQGSV EAISESLIKL STSEVKVNIV 700
    GSGVGGITET DATLAAASGA IVLGFNVRAD ATARRVLEAE EIDLRYYSVI 750
    YNLIDEVKAA MSGMLAPEFK QEIIGLAEVR DVFKSPKLGA IAGCMVTEGN 800
    VKRSNPIRVL RDNVVIYEGE LESLRRFKDD VQDVRNGMEC GIGVKNYNDV 850
    KVGDQIEVFE IVEVKREI 868
    Length:868
    Mass (Da):95,580
    Last modified:September 23, 2008 - v1
    Checksum:i32AA374822B8D3FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001103 Genomic DNA. Translation: AEA97922.1.
    RefSeqiYP_004426920.1. NC_011138.3.

    Genome annotation databases

    EnsemblBacteriaiAEA97922; AEA97922; MADE_1008920.
    GeneIDi10557126.
    KEGGiamc:MADE_1008920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001103 Genomic DNA. Translation: AEA97922.1 .
    RefSeqi YP_004426920.1. NC_011138.3.

    3D structure databases

    ProteinModelPortali B4RXT8.
    SMRi B4RXT8. Positions 2-50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314275.MADE_01760.

    Proteomic databases

    PRIDEi B4RXT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA97922 ; AEA97922 ; MADE_1008920 .
    GeneIDi 10557126.
    KEGGi amc:MADE_1008920.

    Phylogenomic databases

    eggNOGi COG0532.
    KOi K02519.
    OMAi DATGKTR.

    Enzyme and pathway databases

    BioCyci AMAC314275:GHA7-1804-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
      Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
      ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17117 / Deep ecotype.

    Entry informationi

    Entry nameiIF2_ALTMD
    AccessioniPrimary (citable) accession number: B4RXT8
    Secondary accession number(s): F2GAC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3