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B4RXT8

- IF2_ALTMD

UniProt

B4RXT8 - IF2_ALTMD

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi377 – 3848GTPUniRule annotation
Nucleotide bindingi423 – 4275GTPUniRule annotation
Nucleotide bindingi477 – 4804GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMAC314275:GHA7-1804-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:MADE_1008920
OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
Taxonomic identifieri314275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000001870: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 868868Translation initiation factor IF-2PRO_1000093755Add
BLAST

Proteomic databases

PRIDEiB4RXT8.

Interactioni

Protein-protein interaction databases

STRINGi314275.MADE_01760.

Structurei

3D structure databases

ProteinModelPortaliB4RXT8.
SMRiB4RXT8. Positions 2-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini368 – 537170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni377 – 3848G1By similarity
Regioni402 – 4065G2By similarity
Regioni423 – 4264G3By similarity
Regioni477 – 4804G4By similarity
Regioni513 – 5153G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
KOiK02519.
OMAiDATGKTR.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4RXT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADVSIEKLA SDIGTTVDRL VGQFKDAGIS KSAGEQVNED EKQKLLDHLS
60 70 80 90 100
KQHGSAAEPT RMTLKRKTTS TLSVGKSKEV KVEVRKKRTY VKRSDIEEQQ
110 120 130 140 150
RQAEEEAKRL EEEARLKREA EEKAAAEAKK AAEEKARKAQ EAKKAAEEER
160 170 180 190 200
VRRAEQAKKE AEARKKDEPE LTEAEKAEAE AARQEEERLR KAQEEEAQKK
210 220 230 240 250
LEEDAKKAAD EARKLAEENE RRWKEEEERR KKAEAEEVHL HSNRYAQEAE
260 270 280 290 300
DEEDMQVERS SRRRRKSKKN AGEHLKQGFN KPAAPVERVV KLGATITVGE
310 320 330 340 350
LASKLAIKSN EVIKTMMKMG EMATINQVLD QDTAVLVIEE MGHKYELVND
360 370 380 390 400
NALEDELLAD GTDGEKTSRA PVVTIMGHVD HGKTSLLDYI RRAKVADGEA
410 420 430 440 450
GGITQHIGAY KVQTDNGEIT FLDTPGHAAF TAMRARGATA TDIVILVVAA
460 470 480 490 500
DDGVMPQTKE AVQHARAAGV PLIVAVNKMD KETADPDRVK TELSQLEVIS
510 520 530 540 550
EEWGGEHQFC NVSAKTGMGV DELLEAIVLQ SELLDLQAVA EGPGRGIVIE
560 570 580 590 600
SRLDKGRGPV ASVLVQEGQL RAGDILLCGE EYGRVRAMRD ENGKDMKLAG
610 620 630 640 650
PSTPVEVLGL SGVPVAGEDA AVVKDERKAR EVAAKRHQKK RELKLARQQK
660 670 680 690 700
AKLENMFANM ESGDVSELNI VLKADVQGSV EAISESLIKL STSEVKVNIV
710 720 730 740 750
GSGVGGITET DATLAAASGA IVLGFNVRAD ATARRVLEAE EIDLRYYSVI
760 770 780 790 800
YNLIDEVKAA MSGMLAPEFK QEIIGLAEVR DVFKSPKLGA IAGCMVTEGN
810 820 830 840 850
VKRSNPIRVL RDNVVIYEGE LESLRRFKDD VQDVRNGMEC GIGVKNYNDV
860
KVGDQIEVFE IVEVKREI
Length:868
Mass (Da):95,580
Last modified:September 23, 2008 - v1
Checksum:i32AA374822B8D3FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001103 Genomic DNA. Translation: AEA97922.1.
RefSeqiYP_004426920.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA97922; AEA97922; MADE_1008920.
GeneIDi10557126.
KEGGiamc:MADE_1008920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001103 Genomic DNA. Translation: AEA97922.1 .
RefSeqi YP_004426920.1. NC_011138.3.

3D structure databases

ProteinModelPortali B4RXT8.
SMRi B4RXT8. Positions 2-50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314275.MADE_01760.

Proteomic databases

PRIDEi B4RXT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA97922 ; AEA97922 ; MADE_1008920 .
GeneIDi 10557126.
KEGGi amc:MADE_1008920.

Phylogenomic databases

eggNOGi COG0532.
KOi K02519.
OMAi DATGKTR.

Enzyme and pathway databases

BioCyci AMAC314275:GHA7-1804-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
    Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
    ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17117 / Deep ecotype.

Entry informationi

Entry nameiIF2_ALTMD
AccessioniPrimary (citable) accession number: B4RXT8
Secondary accession number(s): F2GAC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3