Reviewed, UniProtKB/Swiss-Prot B4RX41 (G6PI_ALTMD)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	MADE_03322

Organism

Alteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP]

Taxonomic identifier

314275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Alteromonas

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000125689
Sites
	Active site	384	1	By similarity
	Active site	512	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4RX41-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 427E29B2312204B3	FASTA	549	60,519
	10 20 30 40 50 60 MSVLTSLPEW KNLSDIAASV KSAHMRDWFA QDTSRADKMQ LEACGIFLDY SKNRVNEDAL 70 80 90 100 110 120 KGLFDLARAC KLETLRDAMF SGEQINSTEG RAVLHTALRN FSDRKVLVDG EDVMPEVHAT 130 140 150 160 170 180 LEKIEAFTAS IHSGEHKGYT GKPIKHIVAI GIGGSFLGPK IMTEALKPHT VDAVKVHFVA 190 200 210 220 230 240 NVDGCHIHDV LSSIDFEETL VVMSSKSFST QETLQNTLTA KDWFLKSGGT QEDIAKHFVA 250 260 270 280 290 300 VSSNVKAATD FGISADNIFP MWDWVGGRYS LWSAIGLPIS LALGFENFKG LLEGAFEMDN 310 320 330 340 350 360 HFTTAPLEEN MPVLLGLLGI WYRNFFDAQS HVLLPYYHYL RGLPAYVQQL DMESNGKEVT 370 380 390 400 410 420 QEGESVDYPT GPIIWGSEGT NGQHSFHQLI HQGSGVIPAD FMLPLNVPNQ DDTHHAMLAS 430 440 450 460 470 480 NCFGQTQALM QGKSFEECYA DLDGKGLDDA ERKRLAAHKT MPGNKPSNTF LFDSLTPQTL 490 500 510 520 530 540 GALVAMYEHK VFVQGVIWNL NSFDQWGVEL GKVLGNQVLA GIQGEADKDN FDASTQQLIA KFRAANAPK

References

[1]

"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter." Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F. ISME J. 2:1194-1212(2008) [PubMed: 18670397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001103 Genomic DNA. Translation: ACG67614.1.
RefSeq	YP_002127608.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6778625.
GenomeReviews	Gene locus MADE_03322 in contig CP001103_GR.
KEGG	amc:MADE_03322.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VDKHFVE.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ALTMD

Accession

Primary (citable) accession number: B4RX41

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)