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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei384 – 3841UniRule annotation
Active sitei512 – 5121UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciAMAC314275:GHA7-3124-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:MADE_1015455
OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
Taxonomic identifieri314275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000001870 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomerasePRO_1000125689Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314275.MADE_03322.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiFELANDC.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4RX41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLTSLPEW KNLSDIAASV KSAHMRDWFA QDTSRADKMQ LEACGIFLDY
60 70 80 90 100
SKNRVNEDAL KGLFDLARAC KLETLRDAMF SGEQINSTEG RAVLHTALRN
110 120 130 140 150
FSDRKVLVDG EDVMPEVHAT LEKIEAFTAS IHSGEHKGYT GKPIKHIVAI
160 170 180 190 200
GIGGSFLGPK IMTEALKPHT VDAVKVHFVA NVDGCHIHDV LSSIDFEETL
210 220 230 240 250
VVMSSKSFST QETLQNTLTA KDWFLKSGGT QEDIAKHFVA VSSNVKAATD
260 270 280 290 300
FGISADNIFP MWDWVGGRYS LWSAIGLPIS LALGFENFKG LLEGAFEMDN
310 320 330 340 350
HFTTAPLEEN MPVLLGLLGI WYRNFFDAQS HVLLPYYHYL RGLPAYVQQL
360 370 380 390 400
DMESNGKEVT QEGESVDYPT GPIIWGSEGT NGQHSFHQLI HQGSGVIPAD
410 420 430 440 450
FMLPLNVPNQ DDTHHAMLAS NCFGQTQALM QGKSFEECYA DLDGKGLDDA
460 470 480 490 500
ERKRLAAHKT MPGNKPSNTF LFDSLTPQTL GALVAMYEHK VFVQGVIWNL
510 520 530 540
NSFDQWGVEL GKVLGNQVLA GIQGEADKDN FDASTQQLIA KFRAANAPK
Length:549
Mass (Da):60,519
Last modified:September 23, 2008 - v1
Checksum:i427E29B2312204B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA99223.1.
RefSeqiWP_012519515.1. NC_011138.3.
YP_004428221.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA99223; AEA99223; MADE_1015455.
GeneIDi10558441.
KEGGiamc:MADE_1015455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA99223.1.
RefSeqiWP_012519515.1. NC_011138.3.
YP_004428221.1. NC_011138.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314275.MADE_03322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA99223; AEA99223; MADE_1015455.
GeneIDi10558441.
KEGGiamc:MADE_1015455.

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiFELANDC.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciAMAC314275:GHA7-3124-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
    Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
    ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17117 / Deep ecotype.

Entry informationi

Entry nameiG6PI_ALTMD
AccessioniPrimary (citable) accession number: B4RX41
Secondary accession number(s): F2GD87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: April 1, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.