Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase

Gene

katG

Organism
Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei119 – 1191Transition state stabilizerUniRule annotation
Active sitei123 – 1231Proton acceptorUniRule annotation
Metal bindingi285 – 2851Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciAMAC314275:GHA7-3347-MONOMER.

Protein family/group databases

PeroxiBasei7308. AmacCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:MADE_1016605
OrganismiAlteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Taxonomic identifieri1774373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
Proteomesi
  • UP000001870 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626UniRule annotationAdd
BLAST
Chaini27 – 766740Catalase-peroxidasePRO_0000354720Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki122 ↔ 244Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-270)UniRule annotation
Cross-linki244 ↔ 270Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-122)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB4RW28.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi314275.MADE_1016605.

Structurei

3D structure databases

ProteinModelPortaliB4RW28.
SMRiB4RW28. Positions 48-757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
KOiK03782.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4RW28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMNRFRKTT LSALVALSLG ATGAIANDQI SKPAGAKGTG MTKAFQPKSN
60 70 80 90 100
QFWWPDQLDL SPLRDHDNRS NPLGEDFDYA KAFSKLDLDQ VKSDINELLT
110 120 130 140 150
TSQDWWPADF GNYGPFFIRL SWHSAGTYRT LDGRGGGDGG QMRFDPLNSW
160 170 180 190 200
PDNGNLDKAR RLLWPIKQKY GESLSWGDLM ILAGTVGMEN MGFDTYGFAG
210 220 230 240 250
GRTDDWEPDM VYWGPEVEML ASDREEREGK LQRPLGATHM GLIYVNPEGP
260 270 280 290 300
KGVPDPMGSA KNIRTAFARM AMNDEETVAL IAGGHTFGKM HGAHKPADCL
310 320 330 340 350
EAEPGGAGLE EQGLGWKNNC GKGNAEDTVT SGLEGAWTQL PTKWTSLYLQ
360 370 380 390 400
NLLGFEWKQT RSPAGAIQWV PTDESLHTSV PDAHVEGKKN PPVMTTADLA
410 420 430 440 450
LKYDPEYRKI AERFLADPKE YQTAFAKAWF KLTHRDMGPK ERYLGNDIPR
460 470 480 490 500
ENFIWQDPVP KADYKTISDK DVKKLKADIL DSGLTVQQLV KTAWAGASSF
510 520 530 540 550
RASDLRGGAN GARIALEPQM SWEANEPETV KAVVAKLKEL QEDYNSRMFS
560 570 580 590 600
KKKVSLADLI VIGGAAAIEK AAADAGVEVS VPVVPGRTDA TQEQTDVNSF
610 620 630 640 650
SLLEPTADAF RNYYNAEASY RSPTDMLVDK ADQLNLTVPE MTVLLGGLRS
660 670 680 690 700
LGANTGGTNH GVFTDNVGTL NNDFFVTLLD MGVKWRKTDD ASVYEGVNRS
710 720 730 740 750
TGEVMYTGTP VDLVFGSNSE LRAVAEVYAY DNAKTRFVED FVDAWTKVMT
760
LDRFDLRHDL NAKLAK
Length:766
Mass (Da):84,458
Last modified:October 19, 2011 - v2
Checksum:iDB68CFA186110ADF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA99445.1.
RefSeqiWP_012519733.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA99445; AEA99445; MADE_1016605.
GeneIDi10558662.
KEGGiamc:MADE_1016605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA99445.1.
RefSeqiWP_012519733.1. NC_011138.3.

3D structure databases

ProteinModelPortaliB4RW28.
SMRiB4RW28. Positions 48-757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314275.MADE_1016605.

Protein family/group databases

PeroxiBasei7308. AmacCP01.

Proteomic databases

PRIDEiB4RW28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA99445; AEA99445; MADE_1016605.
GeneIDi10558662.
KEGGiamc:MADE_1016605.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
KOiK03782.

Enzyme and pathway databases

BioCyciAMAC314275:GHA7-3347-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_ALTMD
AccessioniPrimary (citable) accession number: B4RW28
Secondary accession number(s): F2G4D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 19, 2011
Last modified: June 8, 2016
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.