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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD)
  2. no protein annotated in this organism
  3. Succinyl-diaminopimelate desuccinylase 2 (dapE2), Succinyl-diaminopimelate desuccinylase 1 (dapE1)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00034; UER00019

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
Ordered Locus Names:MADE_1004950
OrganismiAlteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Taxonomic identifieri1774373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
Proteomesi
  • UP000001870 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001340271 – 2742,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseAdd BLAST274

Proteomic databases

PRIDEiB4RVP7

Structurei

3D structure databases

ProteinModelPortaliB4RVP7
SMRiB4RVP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DMJ Bacteria
COG2171 LUCA
KOiK00674
OMAiQVPCALI

Family and domain databases

Gene3Di1.10.166.10, 1 hit
HAMAPiMF_00811 DapD, 1 hit
InterProiView protein in InterPro
IPR005664 DapD_Trfase_Hexpep_rpt_fam
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR023180 THP_succinylTrfase_dom1
IPR037133 THP_succinylTrfase_N_sf
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF14602 Hexapep_2, 1 hit
PF14805 THDPS_N_2, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR00965 dapD, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 1 hit

Sequencei

Sequence statusi: Complete.

B4RVP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELKAIIED AFENRDSISP SSAPDEVRDA VAQAIDLLNS GKGRVAEKIA
60 70 80 90 100
GEWVVHQWLK KAVLLFFRLH NNDVIEGAES KFYDKVPLKY TNYTAEQFAA
110 120 130 140 150
DGARIVPPAA VRTGTFVGKN AVVMPSYVNI GAFVDEGTMV DTWATVGSCA
160 170 180 190 200
QIGKNVHLSG GVGIGGVLEP LQANPTIIED NCFIGARSEI VEGVIVEEGS
210 220 230 240 250
VISMGVYIGQ STRIYDRETG EIHYGRVPAG SVVVAGNLPS ADGKYSLYAA
260 270
IIVKKVDAKT RAKVGINALL RGVE
Length:274
Mass (Da):29,280
Last modified:September 23, 2008 - v1
Checksum:iBEE513784EFAED22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA Translation: AEA97136.1
RefSeqiWP_012517490.1, NC_011138.3

Genome annotation databases

EnsemblBacteriaiAEA97136; AEA97136; MADE_1004950
KEGGiamc:MADE_1004950

Similar proteinsi

Entry informationi

Entry nameiDAPD_ALTMD
AccessioniPrimary (citable) accession number: B4RVP7
Secondary accession number(s): F2GBY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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