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B4RVJ5

- LPXB_ALTMD

UniProt

B4RVJ5 - LPXB_ALTMD

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, MADE_1005380
Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAMAC314275:GHA7-1093-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:MADE_1005380
OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
Taxonomic identifieri314275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000001870: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthaseUniRule annotationPRO_1000191459Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314275.MADE_01385.

Structurei

3D structure databases

ProteinModelPortaliB4RVJ5.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiVSPITYR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RVJ5-1 [UniParc]FASTAAdd to Basket

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MSKPIRIGMV AGEPSGDILA AGMVAELKRQ YPDAIIEGIG GPNMIDAGFH    50
SLFDMETLSV MGLVEVLAHL PAILKVKKQL LAHFEQNPPD IFVGVDAPDF 100
NLRVEKALKA RGIKTMHYVS PTVWAWREKR IHKIAKAANR VLGLFPFEQQ 150
VYDKYHVPYT FVGHTMADAI AIEPDQNAAR QELGVESNAY VLAVLPGSRR 200
GEVETLLPVF LETIEAIHVK RSDIQFLIPA ANEHRLAQIK AFLQEANNAE 250
ERLPIQVTQG TSRDAMIASD VILLASGTAT LEAMLCKRPM VAAYLLSPLT 300
YKIMQRLYKA PFFTLPNLLA NEAIIPELLQ EEVNAENMSN QLLNFFESDN 350
SALIARFTDL HHTLKCNADK TAAKAVVEEL FA 382
Length:382
Mass (Da):42,334
Last modified:September 23, 2008 - v1
Checksum:i71832D847E3CC0F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001103 Genomic DNA. Translation: AEA97222.1.
RefSeqiYP_004426220.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA97222; AEA97222; MADE_1005380.
GeneIDi10556419.
KEGGiamc:MADE_1005380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001103 Genomic DNA. Translation: AEA97222.1 .
RefSeqi YP_004426220.1. NC_011138.3.

3D structure databases

ProteinModelPortali B4RVJ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314275.MADE_01385.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA97222 ; AEA97222 ; MADE_1005380 .
GeneIDi 10556419.
KEGGi amc:MADE_1005380.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi VSPITYR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci AMAC314275:GHA7-1093-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
    Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
    ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17117 / Deep ecotype.

Entry informationi

Entry nameiLPXB_ALTMD
AccessioniPrimary (citable) accession number: B4RVJ5
Secondary accession number(s): F2G288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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