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B4RVJ5

- LPXB_ALTMD

UniProt

B4RVJ5 - LPXB_ALTMD

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciAMAC314275:GHA7-1093-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:MADE_1005380
    OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
    Taxonomic identifieri314275 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
    ProteomesiUP000001870: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Lipid-A-disaccharide synthasePRO_1000191459Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314275.MADE_01385.

    Structurei

    3D structure databases

    ProteinModelPortaliB4RVJ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    KOiK00748.
    OMAiVSPITYR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4RVJ5-1 [UniParc]FASTAAdd to Basket

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    MSKPIRIGMV AGEPSGDILA AGMVAELKRQ YPDAIIEGIG GPNMIDAGFH    50
    SLFDMETLSV MGLVEVLAHL PAILKVKKQL LAHFEQNPPD IFVGVDAPDF 100
    NLRVEKALKA RGIKTMHYVS PTVWAWREKR IHKIAKAANR VLGLFPFEQQ 150
    VYDKYHVPYT FVGHTMADAI AIEPDQNAAR QELGVESNAY VLAVLPGSRR 200
    GEVETLLPVF LETIEAIHVK RSDIQFLIPA ANEHRLAQIK AFLQEANNAE 250
    ERLPIQVTQG TSRDAMIASD VILLASGTAT LEAMLCKRPM VAAYLLSPLT 300
    YKIMQRLYKA PFFTLPNLLA NEAIIPELLQ EEVNAENMSN QLLNFFESDN 350
    SALIARFTDL HHTLKCNADK TAAKAVVEEL FA 382
    Length:382
    Mass (Da):42,334
    Last modified:September 23, 2008 - v1
    Checksum:i71832D847E3CC0F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001103 Genomic DNA. Translation: AEA97222.1.
    RefSeqiYP_004426220.1. NC_011138.3.

    Genome annotation databases

    EnsemblBacteriaiAEA97222; AEA97222; MADE_1005380.
    GeneIDi10556419.
    KEGGiamc:MADE_1005380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001103 Genomic DNA. Translation: AEA97222.1 .
    RefSeqi YP_004426220.1. NC_011138.3.

    3D structure databases

    ProteinModelPortali B4RVJ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314275.MADE_01385.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA97222 ; AEA97222 ; MADE_1005380 .
    GeneIDi 10556419.
    KEGGi amc:MADE_1005380.

    Phylogenomic databases

    eggNOGi COG0763.
    KOi K00748.
    OMAi VSPITYR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci AMAC314275:GHA7-1093-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
      Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
      ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17117 / Deep ecotype.

    Entry informationi

    Entry nameiLPXB_ALTMD
    AccessioniPrimary (citable) accession number: B4RVJ5
    Secondary accession number(s): F2G288
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3