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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Alteromonas macleodii (strain DSM 17117 / Deep ecotype)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAMAC314275:GHA7-1093-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:MADE_1005380
OrganismiAlteromonas macleodii (strain DSM 17117 / Deep ecotype)
Taxonomic identifieri314275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000001870 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthasePRO_1000191459Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314275.MADE_01385.

Structurei

3D structure databases

ProteinModelPortaliB4RVJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiQPWVGLP.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RVJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPIRIGMV AGEPSGDILA AGMVAELKRQ YPDAIIEGIG GPNMIDAGFH
60 70 80 90 100
SLFDMETLSV MGLVEVLAHL PAILKVKKQL LAHFEQNPPD IFVGVDAPDF
110 120 130 140 150
NLRVEKALKA RGIKTMHYVS PTVWAWREKR IHKIAKAANR VLGLFPFEQQ
160 170 180 190 200
VYDKYHVPYT FVGHTMADAI AIEPDQNAAR QELGVESNAY VLAVLPGSRR
210 220 230 240 250
GEVETLLPVF LETIEAIHVK RSDIQFLIPA ANEHRLAQIK AFLQEANNAE
260 270 280 290 300
ERLPIQVTQG TSRDAMIASD VILLASGTAT LEAMLCKRPM VAAYLLSPLT
310 320 330 340 350
YKIMQRLYKA PFFTLPNLLA NEAIIPELLQ EEVNAENMSN QLLNFFESDN
360 370 380
SALIARFTDL HHTLKCNADK TAAKAVVEEL FA
Length:382
Mass (Da):42,334
Last modified:September 23, 2008 - v1
Checksum:i71832D847E3CC0F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA97222.1.
RefSeqiWP_012517576.1. NC_011138.3.
YP_004426220.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA97222; AEA97222; MADE_1005380.
GeneIDi10556419.
KEGGiamc:MADE_1005380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA97222.1.
RefSeqiWP_012517576.1. NC_011138.3.
YP_004426220.1. NC_011138.3.

3D structure databases

ProteinModelPortaliB4RVJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314275.MADE_01385.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA97222; AEA97222; MADE_1005380.
GeneIDi10556419.
KEGGiamc:MADE_1005380.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiQPWVGLP.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciAMAC314275:GHA7-1093-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
    Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
    ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17117 / Deep ecotype.

Entry informationi

Entry nameiLPXB_ALTMD
AccessioniPrimary (citable) accession number: B4RVJ5
Secondary accession number(s): F2G288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: April 29, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.