B4RUW0 (MSRB_ALTMD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	MADE_1011650

Organism

Alteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP]

Taxonomic identifier

314275 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Alteromonas › Alteromonas macleodii

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP-Rule MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine (S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Peptide methionine sulfoxide reductase MsrB HAMAP-Rule MF_01400		PRO_1000145349
Sites
	Active site	124	1	Nucleophile By similarity
	Metal binding	52	1	Zinc By similarity
	Metal binding	55	1	Zinc By similarity
	Metal binding	101	1	Zinc By similarity
	Metal binding	104	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4RUW0 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: BDD9F2A8572BFBE6	FASTA	142	16,080
	10 20 30 40 50 60 MSTDKKQDES IAEKDWKVEL SEQEYYVCRE AGTERPFTGV LLDEQRDGLY VCKCCEAPLF 70 80 90 100 110 120 PSDTKFDAGC GWPSFYKQLD DGNVDYREDV SHGMRRVEIF CKQCGSHLGH VFPDGPAPTG 130 140 QRYCVNSLSM TFKGEDNVEV KG

References

[1]

"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter." Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F. ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17117 / Deep ecotype.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001103 Genomic DNA. Translation: AEA98466.1.
RefSeq	YP_004427464.1. NC_011138.2.
3D structure databases
ProteinModelPortal	B4RUW0.
ModBase	Search...
Protein-protein interaction databases
STRING	314275.MADE_01256.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEA98466; AEA98466; MADE_1011650.
GeneID	10557674.
KEGG	amc:MADE_1011650.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
KO	K07305.
OMA	EIRCGQC.
Enzyme and pathway databases
BioCyc	AMAC314275:GHA7-2354-MONOMER.
Family and domain databases
Gene3D	2.170.150.20. 1 hit.
HAMAP	MF_01400. MsrB.
InterPro	IPR002579. Met_Sox_Rdtase_MsrB. IPR011057. Mss4-like. [Graphical view]
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_ALTMD

Accession

Primary (citable) accession number: B4RUW0
Secondary accession number(s): F2G566

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program