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Protein

3-ketoacyl-CoA thiolase

Gene

fadI

Organism
Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Acyl-thioester intermediateUniRule annotation1
Active sitei392Proton acceptorUniRule annotation1
Active sitei422Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
ACSsUniRule annotation
Acetyl-CoA acyltransferaseUniRule annotation
Acyl-CoA ligaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadIUniRule annotation
Ordered Locus Names:MADE_1006800
OrganismiAlteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Taxonomic identifieri1774373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
Proteomesi
  • UP000001870 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001859561 – 4363-ketoacyl-CoA thiolaseAdd BLAST436

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4RTU9.
SMRiB4RTU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
KOiK00632.

Family and domain databases

CDDicd00751. thiolase. 1 hit.
Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01618. FadI. 1 hit.
InterProiView protein in InterPro
IPR012806. Ac-CoA_C-AcTrfase_FadI.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020616. Thiolase_N.
PANTHERiPTHR18919:SF113. PTHR18919:SF113. 1 hit.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02446. FadI. 1 hit.
PROSITEiView protein in PROSITE
PS00099. THIOLASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RTU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKQSVTTR EGDRIAIVAG LRTPFAKMAT YFHGVPAVDL GKMVVNELLV
60 70 80 90 100
RHGVQKEWVD QVVYGQVVQM PEAPNIAREI VLGTGMNVHT DAYSVSRACA
110 120 130 140 150
TSFQSTVNIA ESMMAGTVQV GIAGGADSTS VSPIGVSKNL ARALVDLQKT
160 170 180 190 200
KTLGQKLNIF KRLSLRDLAP VPPAVAEYST GLSMGQTAEQ MAKTHQISRE
210 220 230 240 250
EQDKLAHRSH SLAAESWEAG KLSSEVMTAY AEPYKAALER DNNVRFDSKL
260 270 280 290 300
EGYAKLRPVF DKKYGSVTAA NATPLTDGAS AVLMMTESRA KELGYTPLGY
310 320 330 340 350
IKSYAFAAID VWEDMLMGPS YATPIALDRA GMTLNDLTLI EMHEAFAAQT
360 370 380 390 400
LANVKMFASD KFAKEKLGRD KATGEIDMDK FNVMGSSIAY GHPFAATGTR
410 420 430
MITQMLNELN RRGGGSGLLT ACAAGGLGAA MIVETE
Length:436
Mass (Da):46,823
Last modified:September 23, 2008 - v1
Checksum:i6BDA46C831F9D4CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA97502.1.
RefSeqiWP_012517844.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA97502; AEA97502; MADE_1006800.
KEGGiamc:MADE_1006800.

Similar proteinsi

Entry informationi

Entry nameiFADI_ALTMD
AccessioniPrimary (citable) accession number: B4RTU9
Secondary accession number(s): F2G5T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families