B4RSJ5 (GCST_ALTMD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	MADE_1014435

Organism

Alteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP]

Taxonomic identifier

314275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Alteromonas

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Aminomethyltransferase HAMAP MF_00259		PRO_1000114077

Sequences

	Sequence		Length	Mass (Da)
	B4RSJ5 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 5B9F18925D204468	FASTA	359	39,296
	10 20 30 40 50 60 MSSTTALHTK HLEAGAKMVD FFGWDMPINY GSQIEEHHAV RQDAGMFDVS HMTIVDVKGA 70 80 90 100 110 120 QAKAYLQYLL ANDVAKLKDK GKALYSGMLN EEGGVVDDLI VYHFDETNYR LVVNSATREK 130 140 150 160 170 180 DMNWLMSKAE GFDVTITERP EFAMIAVQGP NAKEKAATLF SAAQKEAVAG MKPFFGVQAE 190 200 210 220 230 240 DLFIATTGYT GEAGYEIMVP AEQAESFWQA LLDAGVKPCG LGARDTLRLE AGMNLYGQDM 250 260 270 280 290 300 DETVSPLAAN MGWTITWEPA ERDFVGRKAL EAQREAGTDK LVGLVMTEKG VLRHGLKVKT 310 320 330 340 350 ESGEGVITSG TFSPTLGHSI AMARVPRDVG ETVEVEMRKK WVTVKVVKPS FVRNGKSVL

References

[1]

"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter." Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F. ISME J. 2:1194-1212(2008) [PubMed: 18670397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17117 / Deep ecotype.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001103 Genomic DNA. Translation: AEA99021.1.
RefSeq	YP_004428019.1. NC_011138.2.
3D structure databases
ProteinModelPortal	B4RSJ5.
SMR	B4RSJ5. Positions 5-358.
ModBase	Search...
Protein-protein interaction databases
STRING	B4RSJ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10558239.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_ALTMD

Accession

Primary (citable) accession number: B4RSJ5
Secondary accession number(s): F2GBH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program