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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Neisseria gonorrhoeae (strain NCCP11945)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciNGON521006:GJ73-2565-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
Alternative name(s):
L/F-transferaseUniRule annotation
LeucyltransferaseUniRule annotation
PhenyalanyltransferaseUniRule annotation
Gene namesi
Name:aatUniRule annotation
Ordered Locus Names:NGK_2496
OrganismiNeisseria gonorrhoeae (strain NCCP11945)
Taxonomic identifieri521006 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002564 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Leucyl/phenylalanyl-tRNA--protein transferasePRO_1000131931Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB4RR38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102325.
KOiK00684.
OMAiYRQGIFP.
OrthoDBiEOG6WX4R3.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RR38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIPLLAPDN YAFPDPAYAL ARCDGLVGVS RDLDAGRLLE AYRNGVFPWF
60 70 80 90 100
SRDGWFFWYA VGPRAVIVPE RLHVPRSLAK TLRNGSYRVA VNGCFAEVVA
110 120 130 140 150
HCAAAARPNQ DGTWIAPEFQ TAYLKLHEMG HAHSFECHYP DENGKTRLAG
160 170 180 190 200
GFYGVQIGRV FYGESMFALQ PDASKIAFAC AVPFLADLGV ELIDCQQDTE
210 220 230 240
HMRRFGSELL PFADFAERLR MLNAVPLKEE IGRREVACKG L
Length:241
Mass (Da):26,901
Last modified:September 23, 2008 - v1
Checksum:iCC5C7A13D54E7930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001050 Genomic DNA. Translation: ACF31096.1.
RefSeqiWP_003689990.1. NC_011035.1.

Genome annotation databases

EnsemblBacteriaiACF31096; ACF31096; NGK_2496.
KEGGingk:NGK_2496.
PATRICi20343744. VBINeiGon87511_2704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001050 Genomic DNA. Translation: ACF31096.1.
RefSeqiWP_003689990.1. NC_011035.1.

3D structure databases

ProteinModelPortaliB4RR38.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF31096; ACF31096; NGK_2496.
KEGGingk:NGK_2496.
PATRICi20343744. VBINeiGon87511_2704.

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102325.
KOiK00684.
OMAiYRQGIFP.
OrthoDBiEOG6WX4R3.

Enzyme and pathway databases

BioCyciNGON521006:GJ73-2565-MONOMER.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Neisseria gonorrhoeae NCCP11945."
    Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.
    J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCCP11945.

Entry informationi

Entry nameiLFTR_NEIG2
AccessioniPrimary (citable) accession number: B4RR38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.