B4RR38 (LFTR_NEIG2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferase
EC=2.3.2.6

Alternative name(s):
L/F-transferase
Leucyltransferase
Phenyalanyltransferase

Gene names

Name:	aat
Ordered Locus Names:	NGK_2496

Organism

Neisseria gonorrhoeae (strain NCCP11945) [Complete proteome] [HAMAP]

Taxonomic identifier

521006 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria gonorrhoeae

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine By similarity. HAMAP-Rule MF_00688
Catalytic activity	L-leucyl-tRNA + protein = tRNA + L-leucyl-protein. HAMAP-Rule MF_00688 L-phenylalanyl-tRNA + protein = tRNA + L-phenylalanyl-protein. HAMAP-Rule MF_00688
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the L/F-transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	leucyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Leucyl/phenylalanyl-tRNA--protein transferase HAMAP-Rule MF_00688		PRO_1000131931

Sequences

	Sequence		Length	Mass (Da)
	B4RR38 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: CC5C7A13D54E7930	FASTA	241	26,901
	10 20 30 40 50 60 MRIPLLAPDN YAFPDPAYAL ARCDGLVGVS RDLDAGRLLE AYRNGVFPWF SRDGWFFWYA 70 80 90 100 110 120 VGPRAVIVPE RLHVPRSLAK TLRNGSYRVA VNGCFAEVVA HCAAAARPNQ DGTWIAPEFQ 130 140 150 160 170 180 TAYLKLHEMG HAHSFECHYP DENGKTRLAG GFYGVQIGRV FYGESMFALQ PDASKIAFAC 190 200 210 220 230 240 AVPFLADLGV ELIDCQQDTE HMRRFGSELL PFADFAERLR MLNAVPLKEE IGRREVACKG L

References

[1]	"Complete genome sequence of Neisseria gonorrhoeae NCCP11945." Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K. J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCCP11945.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001050 Genomic DNA. Translation: ACF31096.1.
RefSeq	YP_002003121.1. NC_011035.1.
3D structure databases
ProteinModelPortal	B4RR38.
ModBase	Search...
Protein-protein interaction databases
STRING	521006.NGK_2496.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACF31096; ACF31096; NGK_2496.
GeneID	6447068.
KEGG	ngk:NGK_2496.
PATRIC	20343744. VBINeiGon87511_2704.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2360.
HOGENOM	HOG000102325.
KO	K00684.
OMA	MFYGESM.
ProtClustDB	PRK00301.
Enzyme and pathway databases
BioCyc	NGON521006:GJ73-2565-MONOMER.
Family and domain databases
HAMAP	MF_00688. Leu_Phe_trans.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR004616. Leu/Phe-tRNA_Trfase. [Graphical view]
Pfam	PF03588. Leu_Phe_trans. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR00667. aat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LFTR_NEIG2

Accession

Primary (citable) accession number: B4RR38

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program