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B4RQ67

- NAGZ_NEIG2

UniProt

B4RQ67 - NAGZ_NEIG2

Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Neisseria gonorrhoeae (strain NCCP11945)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei69 – 691SubstrateUniRule annotation
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei144 – 1441SubstrateUniRule annotation
    Sitei185 – 1851Important for catalytic activityUniRule annotation
    Active sitei187 – 1871Proton donor/acceptorUniRule annotation
    Active sitei258 – 2581NucleophileUniRule annotation

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. peptidoglycan turnover Source: UniProtKB-HAMAP
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciNGON521006:GJ73-184-MONOMER.
    UniPathwayiUPA00544.

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
    Alternative name(s):
    Beta-N-acetylhexosaminidaseUniRule annotation
    N-acetyl-beta-glucosaminidaseUniRule annotation
    Gene namesi
    Name:nagZUniRule annotation
    Ordered Locus Names:NGK_0181
    OrganismiNeisseria gonorrhoeae (strain NCCP11945)
    Taxonomic identifieri521006 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000002564: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Beta-hexosaminidasePRO_1000121064Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi521006.NGK_0181.

    Structurei

    3D structure databases

    ProteinModelPortaliB4RQ67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni174 – 1752Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000248526.
    KOiK01207.
    OMAiLLNGFVW.
    OrthoDBiEOG6BCT06.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    HAMAPiMF_00364. NagZ.
    InterProiIPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00933. Glyco_hydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4RQ67-1 [UniParc]FASTAAdd to Basket

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    MTVPHIPRGP VMADIAAFRL TEEEKQRLLD PAIGGIILFR RNFQNIEQLK    50
    TLTAEIKALR TPELIIAVDH EGGRVQRFIE GFTRLPAMST LGEIWDSEGA 100
    ETAETHAEHI GWVLATELSA CGIDLSFTPV LDLDWGNCAV IGNRSFHRNP 150
    EAVARLALAL QKGLAKGGMK SCGKHFPGHG FVEGDSHLVL PEDGRSLDEL 200
    EAADLAPFRI MSREGMAAVM PAHVVYPQVD TKPAGFSEIW LKQILRRDIG 250
    FKGVIFSDDL TMEGACGAGG IKERARISFE AGCDIILVCN RPDLVDELRD 300
    GFTIPDNQDL AGRWQYMENS LGHEAVQAVI QTTGFQAAQA FVAGLASPQD 350
    TAGGVKVGEA F 361
    Length:361
    Mass (Da):39,211
    Last modified:September 23, 2008 - v1
    Checksum:i437CCCBD9167CA90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001050 Genomic DNA. Translation: ACF28879.1.
    RefSeqiYP_002000806.1. NC_011035.1.

    Genome annotation databases

    EnsemblBacteriaiACF28879; ACF28879; NGK_0181.
    GeneIDi6447749.
    KEGGingk:NGK_0181.
    PATRICi20338639. VBINeiGon87511_0203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001050 Genomic DNA. Translation: ACF28879.1 .
    RefSeqi YP_002000806.1. NC_011035.1.

    3D structure databases

    ProteinModelPortali B4RQ67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 521006.NGK_0181.

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF28879 ; ACF28879 ; NGK_0181 .
    GeneIDi 6447749.
    KEGGi ngk:NGK_0181.
    PATRICi 20338639. VBINeiGon87511_0203.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000248526.
    KOi K01207.
    OMAi LLNGFVW.
    OrthoDBi EOG6BCT06.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci NGON521006:GJ73-184-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    HAMAPi MF_00364. NagZ.
    InterProi IPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00933. Glyco_hydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Neisseria gonorrhoeae NCCP11945."
      Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.
      J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCCP11945.

    Entry informationi

    Entry nameiNAGZ_NEIG2
    AccessioniPrimary (citable) accession number: B4RQ67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3