Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Neisseria gonorrhoeae (strain NCCP11945)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotationSAAS annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:NGK_1559Imported
OrganismiNeisseria gonorrhoeae (strain NCCP11945)Imported
Taxonomic identifieri521006 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000002564 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliB4RN49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 177Nudix hydrolaseInterPro annotationAdd BLAST144

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 87Nudix boxUniRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000066723
KOiK08311
OMAiRPCVGIM

Family and domain databases

CDDicd03671 Ap4A_hydrolase_plant_like, 1 hit
HAMAPiMF_00298 Nudix_RppH, 1 hit
InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR022927 RppH
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR00502 NUDIXFAMILY
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

B4RN49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEPYRPICQ NRPICGKIPR LNLTEGDTVL DREGYRPNVG IILINERNEV
60 70 80 90 100
FWGKRVREHS WQFPQGGIKP GESPETAMYR ELYEEVGLLP QHVKIVGRTR
110 120 130 140 150
DWLRYDVPNN WVRREWRGSY RGQKQIWYLL RLTGRDCDVN LRATRHPEFD
160 170 180 190 200
GWRWHQYWAP VDEVIDFKRD VYLGALKELS SRFLRGMESY EDFAARQPSG

NR
Length:202
Mass (Da):24,150
Last modified:September 23, 2008 - v1
Checksum:iB683A87C96D987CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001050 Genomic DNA Translation: ACF30213.1
RefSeqiWP_003703769.1, NC_011035.1

Genome annotation databases

EnsemblBacteriaiACF30213; ACF30213; NGK_1559
KEGGingk:NGK_1559

Similar proteinsi

Entry informationi

Entry nameiB4RN49_NEIG2
AccessioniPrimary (citable) accession number: B4RN49
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health