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B4RN40 (GCSP_NEIG2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:NGK_1550
OrganismNeisseria gonorrhoeae (strain NCCP11945) [Complete proteome] [HAMAP]
Taxonomic identifier521006 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length950 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 950950Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000132444

Amino acid modifications

Modified residue6981N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4RN40 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: B999CDC250A03C43

FASTA950104,165
        10         20         30         40         50         60 
MKLSELFNPN EFAARHLSFG DEAALLAAVG EKSMDDFVGN TLPQSIRMPS ELDLPEALTE 

        70         80         90        100        110        120 
ADALAKLKGI ASKNVINKSY IGLGYYPTRV PNVILRNVLE NPGWYTAYTP YQAEIAQGRL 

       130        140        150        160        170        180 
EALLNFQQVC IDLTGFPVAG ASLLDEATAA AEAMAMAHRV GKVKSERFFV DARVYPQTLD 

       190        200        210        220        230        240 
VMKTRAKYFG FELVVSDFAQ ADEGEYFGAL FQYVGKDGDV QDLQDVIGRL KAKGTIVAVA 

       250        260        270        280        290        300 
ADIMSLVLLK SPAELGADIA LGNTQRFGVP MGFGGPHAAY FAFKDEFKRS APGRIIGVSK 

       310        320        330        340        350        360 
DASGKPALRM ALSTREQHIR REKATSNICT AQALLTNLAG MYAVYHGPKG VKRIANRIHT 

       370        380        390        400        410        420 
LASVFADALV SDGLKVVHEV FFDTVTVDFG SKEKADQVFA AALESGYNLR RVNNTQVAAA 

       430        440        450        460        470        480 
FHETSVYEDL ADLYRAFTGK DTFTFADDVK GRLNAELLRQ DDILQHPVYN SYHTEHEMLR 

       490        500        510        520        530        540 
YLKKLEDRDL AMNRSMISLG SCTMKLNATA EMLPITWTEF SDIHPYAPEA QTAGYRELLA 

       550        560        570        580        590        600 
DMENSLKAIT GFDAISFQPN SGAQGEYSGM LAIRRYQEAQ GEAHRNICLI PKSAHGTNPA 

       610        620        630        640        650        660 
TAAMLGLKVV VVDTDEHGNV NIDDLKAKAE QHRDALSAIM ITYPSTHGVY EEGIRDICRI 

       670        680        690        700        710        720 
IHENGGQVYM DGANLNAQIG IMQPAEVGAD VLHMNLHKTF CIPHGGGGPG MGPIGLKAHL 

       730        740        750        760        770        780 
APFAPGHTLT DTHSASAGQT SVAAAAFGSA SILPITWMYL TMMGKQGMEQ ATRWALLNAN 

       790        800        810        820        830        840 
YVAKRLSEDY PILYTGKNGR IAHECIVDLR PLKAESGITE TDIAKRLMDY GFHAPTVSFP 

       850        860        870        880        890        900 
VAGTLMIEPT ESESKAELDR FIAALKSIRR EVQKVIDGEW PKDDNPLVNA PHTAADITGE 

       910        920        930        940        950 
WAHPYSREEA VFPLPFVREH KFWPFVNRVD DVYGDRNLVC SCPPMENYED 

« Hide

References

[1]"Complete genome sequence of Neisseria gonorrhoeae NCCP11945."
Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.
J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCCP11945.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001050 Genomic DNA. Translation: ACF30206.1.
RefSeqYP_002002175.1. NC_011035.1.

3D structure databases

ProteinModelPortalB4RN40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521006.NGK_1550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACF30206; ACF30206; NGK_1550.
GeneID6447799.
KEGGngk:NGK_1550.
PATRIC20341580. VBINeiGon87511_1651.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycNGON521006:GJ73-1580-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_NEIG2
AccessionPrimary (citable) accession number: B4RN40
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families