SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B4RN40

- GCSP_NEIG2

UniProt

B4RN40 - GCSP_NEIG2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, NGK_1550
Organism
Neisseria gonorrhoeae (strain NCCP11945)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNGON521006:GJ73-1580-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:NGK_1550
OrganismiNeisseria gonorrhoeae (strain NCCP11945)
Taxonomic identifieri521006 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002564: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000132444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei698 – 6981N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi521006.NGK_1550.

Structurei

3D structure databases

ProteinModelPortaliB4RN40.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RN40-1 [UniParc]FASTAAdd to Basket

« Hide

MKLSELFNPN EFAARHLSFG DEAALLAAVG EKSMDDFVGN TLPQSIRMPS    50
ELDLPEALTE ADALAKLKGI ASKNVINKSY IGLGYYPTRV PNVILRNVLE 100
NPGWYTAYTP YQAEIAQGRL EALLNFQQVC IDLTGFPVAG ASLLDEATAA 150
AEAMAMAHRV GKVKSERFFV DARVYPQTLD VMKTRAKYFG FELVVSDFAQ 200
ADEGEYFGAL FQYVGKDGDV QDLQDVIGRL KAKGTIVAVA ADIMSLVLLK 250
SPAELGADIA LGNTQRFGVP MGFGGPHAAY FAFKDEFKRS APGRIIGVSK 300
DASGKPALRM ALSTREQHIR REKATSNICT AQALLTNLAG MYAVYHGPKG 350
VKRIANRIHT LASVFADALV SDGLKVVHEV FFDTVTVDFG SKEKADQVFA 400
AALESGYNLR RVNNTQVAAA FHETSVYEDL ADLYRAFTGK DTFTFADDVK 450
GRLNAELLRQ DDILQHPVYN SYHTEHEMLR YLKKLEDRDL AMNRSMISLG 500
SCTMKLNATA EMLPITWTEF SDIHPYAPEA QTAGYRELLA DMENSLKAIT 550
GFDAISFQPN SGAQGEYSGM LAIRRYQEAQ GEAHRNICLI PKSAHGTNPA 600
TAAMLGLKVV VVDTDEHGNV NIDDLKAKAE QHRDALSAIM ITYPSTHGVY 650
EEGIRDICRI IHENGGQVYM DGANLNAQIG IMQPAEVGAD VLHMNLHKTF 700
CIPHGGGGPG MGPIGLKAHL APFAPGHTLT DTHSASAGQT SVAAAAFGSA 750
SILPITWMYL TMMGKQGMEQ ATRWALLNAN YVAKRLSEDY PILYTGKNGR 800
IAHECIVDLR PLKAESGITE TDIAKRLMDY GFHAPTVSFP VAGTLMIEPT 850
ESESKAELDR FIAALKSIRR EVQKVIDGEW PKDDNPLVNA PHTAADITGE 900
WAHPYSREEA VFPLPFVREH KFWPFVNRVD DVYGDRNLVC SCPPMENYED 950
Length:950
Mass (Da):104,165
Last modified:September 23, 2008 - v1
Checksum:iB999CDC250A03C43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001050 Genomic DNA. Translation: ACF30206.1.
RefSeqiWP_012503780.1. NC_011035.1.
YP_002002175.1. NC_011035.1.

Genome annotation databases

EnsemblBacteriaiACF30206; ACF30206; NGK_1550.
GeneIDi6447799.
KEGGingk:NGK_1550.
PATRICi20341580. VBINeiGon87511_1651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001050 Genomic DNA. Translation: ACF30206.1 .
RefSeqi WP_012503780.1. NC_011035.1.
YP_002002175.1. NC_011035.1.

3D structure databases

ProteinModelPortali B4RN40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521006.NGK_1550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF30206 ; ACF30206 ; NGK_1550 .
GeneIDi 6447799.
KEGGi ngk:NGK_1550.
PATRICi 20341580. VBINeiGon87511_1651.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci NGON521006:GJ73-1580-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Neisseria gonorrhoeae NCCP11945."
    Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.
    J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCCP11945.

Entry informationi

Entry nameiGCSP_NEIG2
AccessioniPrimary (citable) accession number: B4RN40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi