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B4RMI6

- TRMB_NEIG2

UniProt

B4RMI6 - TRMB_NEIG2

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Neisseria gonorrhoeae (strain NCCP11945)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701S-adenosyl-L-methionineUniRule annotation
    Binding sitei95 – 951S-adenosyl-L-methionineUniRule annotation
    Binding sitei122 – 1221S-adenosyl-L-methionineUniRule annotation
    Active sitei145 – 1451By similarity
    Binding sitei145 – 1451S-adenosyl-L-methionineUniRule annotation
    Binding sitei149 – 1491SubstrateUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciNGON521006:GJ73-1370-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:NGK_1346
    OrganismiNeisseria gonorrhoeae (strain NCCP11945)
    Taxonomic identifieri521006 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000002564: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238tRNA (guanine-N(7)-)-methyltransferasePRO_1000136358Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi521006.NGK_1346.

    Structurei

    3D structure databases

    ProteinModelPortaliB4RMI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni216 – 2194Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiFATDWEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4RMI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDTAENQTP NDRQAGHPRS IRSFVLRQSH MTAAQQRAID TLWDSFGIDY    50
    QATPADLDAR FGSSRPKILE IGFGMGMASA EIARRLPETD FLAIDVHGPG 100
    VGNLLKLINE NHLENIRVMR HDAVEVVKNM LQDGSLDGIH IFFPDPWHKK 150
    RHHKRRLIQA PFIAKLLPKL KTGGYIHLAT DWEEYAQQML EVLSSFDSLQ 200
    NTAADYAPTP DYRPETKFEA RGKRLGHGVW DLVFKRIG 238
    Length:238
    Mass (Da):26,992
    Last modified:September 23, 2008 - v1
    Checksum:i950918996E5617F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001050 Genomic DNA. Translation: ACF30020.1.
    RefSeqiYP_002001971.1. NC_011035.1.

    Genome annotation databases

    EnsemblBacteriaiACF30020; ACF30020; NGK_1346.
    GeneIDi6447239.
    KEGGingk:NGK_1346.
    PATRICi20341155. VBINeiGon87511_1443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001050 Genomic DNA. Translation: ACF30020.1 .
    RefSeqi YP_002001971.1. NC_011035.1.

    3D structure databases

    ProteinModelPortali B4RMI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 521006.NGK_1346.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF30020 ; ACF30020 ; NGK_1346 .
    GeneIDi 6447239.
    KEGGi ngk:NGK_1346.
    PATRICi 20341155. VBINeiGon87511_1443.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi FATDWEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci NGON521006:GJ73-1370-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Neisseria gonorrhoeae NCCP11945."
      Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.
      J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCCP11945.

    Entry informationi

    Entry nameiTRMB_NEIG2
    AccessioniPrimary (citable) accession number: B4RMI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3