B4RLD8 (PLSY_NEIG2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol-3-phosphate acyltransferase

Alternative name(s):
Acyl-PO4 G3P acyltransferase
Acyl-phosphate--glycerol-3-phosphate acyltransferase
G3P acyltransferase
Short name=GPAT
EC=2.3.1.n3
Lysophosphatidic acid synthase
Short name=LPA synthase

Gene names

Name:	plsY
Ordered Locus Names:	NGK_0948

Organism

Neisseria gonorrhoeae (strain NCCP11945) [Complete proteome] [HAMAP]

Taxonomic identifier

521006 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria gonorrhoeae

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO4) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP By similarity. HAMAP-Rule MF_01043
Catalytic activity	Acyl-phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + phosphate. HAMAP-Rule MF_01043
Pathway	Lipid metabolism; phospholipid metabolism. HAMAP-Rule MF_01043
Subunit structure	Probably interacts with PlsX By similarity. HAMAP-Rule MF_01043
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01043.
Sequence similarities	Belongs to the PlsY family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acyl-phosphate glycerol-3-phosphate acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Glycerol-3-phosphate acyltransferase HAMAP-Rule MF_01043		PRO_1000136103
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B4RLD8 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 4615D9FE92D1E426	FASTA	200	20,752
	10 20 30 40 50 60 MFNIPAVAVS YLIGSLSFAV IVSKYYGMDD PRTYGSGNPG ATNVLRSGKK KAAALTLLGD 70 80 90 100 110 120 AAKGLVAVLL ARVLQEPLGL SDSAIAAVAL AALVGHMWPV FFGFKGGKGV ATALGVLLAL 130 140 150 160 170 180 SPATALVCAL IWLVMAFGFK VSSLAALVAT TAAPLAALFF MPHTSWIFAT LAIAILVLLR 190 200 HKSNILNLIK GKESKIGEKR

References

[1]	"Complete genome sequence of Neisseria gonorrhoeae NCCP11945." Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K. J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCCP11945.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001050 Genomic DNA. Translation: ACF29625.1.
RefSeq	YP_002001573.1. NC_011035.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	521006.NGK_0948.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACF29625; ACF29625; NGK_0948.
GeneID	6449018.
KEGG	ngk:NGK_0948.
PATRIC	20340326. VBINeiGon87511_1030.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0344.
HOGENOM	HOG000283806.
KO	K08591.
OMA	WRHRGNL.
ProtClustDB	CLSK2300446.
Enzyme and pathway databases
BioCyc	NGON521006:GJ73-970-MONOMER.
UniPathway	UPA00085.
Family and domain databases
HAMAP	MF_01043. PlsY.
InterPro	IPR003811. G3P_acylTferase. [Graphical view]
Pfam	PF02660. G3P_acyltransf. 1 hit. [Graphical view]
TIGRFAMs	TIGR00023. TIGR00023. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSY_NEIG2

Accession

Primary (citable) accession number: B4RLD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program