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B4RL61 (B4RL61_NEIG2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:NGK_0871
OrganismNeisseria gonorrhoeae (strain NCCP11945) [Complete proteome] [HAMAP]
Taxonomic identifier521006 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length741 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6261Zinc By similarity HAMAP MF_00172
Metal binding6281Zinc By similarity HAMAP MF_00172
Metal binding7111Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
B4RL61 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: D6CDE395E118A698

FASTA74183,154
        10         20         30         40         50         60 
MKFAQEKYWR KEISEQELLD VAKDLREKNW KHQAAANADY VAVGDFTFYD HILDLQVATG 

        70         80         90        100        110        120 
AIPARFGFDS QNLPLEQFFQ LARGNKDQFA IEMTKWFDTN YHYLVPEFHA DTEFKANAKH 

       130        140        150        160        170        180 
YVQQLQEAQT LGLKAKPTVV GPLTFLWVGK EKGSVEFDRL SLLPKLLPVY VEILTALVEA 

       190        200        210        220        230        240 
GAEWIQIDEP ALAVDLPKEW VEAYKDVYAT LNKVSAKILL GTYFGSVAEH AALLKSLPVD 

       250        260        270        280        290        300 
GLHIDLVRAP EQLDAFAGYD KVLSAGVIDG RNIWRANLNK VLETVGPLQA KLGERLWISS 

       310        320        330        340        350        360 
SCSLLHTPFD LSVEEKLKAN KPDLYSWLAF TLQKTQELRV LKAALNEGRD SVAEELAASQ 

       370        380        390        400        410        420 
AAADSRANSS EIHRADVAKR LADLPVNADQ RKSPFADRIK AQQAWLNLPL LPTTNIGSFP 

       430        440        450        460        470        480 
QTTEIRQARA AFKKGELSAS DYEAAMKKEI ALVVEEQEKL DLDVLVHGEA ERNDMVEYFG 

       490        500        510        520        530        540 
ELLSGFAFTQ YGWVQSYGSR CVKPPIIFGD VSRPEAMTVA WSTYAQNLTK RPMKGMLTGP 

       550        560        570        580        590        600 
VTILQWSFVR NDIPRATVCK QIALALNDEV LDLEKAGIKV IQIDEPAIRE GLPLKRADWD 

       610        620        630        640        650        660 
AYLNWAGESF RLSSAGCEDS TQIHTHMCYS EFNDILPAIA AMDADVITIE TSRSDMELLA 

       670        680        690        700        710        720 
AFGEFKYPND IGPGVYDIHS PRVPTEAEVE HLLRKAIEVV PVERLWVNPD CGLKTRGWKE 

       730        740 
TLEQLQVMMN VTRKLRAELA K

« Hide

References

[1]"Complete genome sequence of Neisseria gonorrhoeae NCCP11945."
Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.
J. Bacteriol. 190:6035-6036(2008) [PubMed: 18586945] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001050 Genomic DNA. Translation: ACF29551.1.
RefSeqYP_002001496.1. NC_011035.1.

3D structure databases

ProteinModelPortalB4RL61.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4RL61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000005991; EBNEIP00000005763; EBNEIG00000005991.
GeneID6448701.
GenomeReviewsGene locus NGK_0871 in contig CP001050_GR.
KEGGngk:NGK_0871.
PATRIC20340146. VBINeiGon87511_0940.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000021045.
HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB4RL61_NEIG2
AccessionPrimary (citable) accession number: B4RL61
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info