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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Neisseria gonorrhoeae (strain NCCP11945)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:NGK_0833
OrganismiNeisseria gonorrhoeae (strain NCCP11945)
Taxonomic identifieri521006 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000002564 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001294751 – 402Nicotinate phosphoribosyltransferaseAdd BLAST402

Structurei

3D structure databases

ProteinModelPortaliB4RL23
SMRiB4RL23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000284928
KOiK00763
OMAiMGFEIFV

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

B4RL23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGIIHSLLD TDLYKFTMLQ VVLHQFPQTH SLYEFRCRNV STVYPLADIR
60 70 80 90 100
EDLEAELDAL CRLRFTHDEL GYLRSLRFIK SDFVDYLELF QLQRRFVEVG
110 120 130 140 150
TDDKGRLNIR IEGPMIQAMF FEIFILAIVN ELYFRRLETP AVIEEGERRL
160 170 180 190 200
QAKAARLKEI AAAQNPDEPP FLISDFGTRR RYKLAWQEHV IRTLLEAAPS
210 220 230 240 250
IVRGTSNVYL AKKLGITPIG TMAHEFLQAF QALDVRLRNF QKAALESWVH
260 270 280 290 300
EYRGDLGVAL TDVVGMDAFL RDFDLYFAKL FDGLRHDSGD PYVWGDKAYA
310 320 330 340 350
HYQKLKIDSR TKMLTFSDGL DIERSWALHQ YFKGRFKTGF GIGTNLTNDM
360 370 380 390 400
GHTPLNIVLK LVECNGQSVA KLSDSPGKTM TNNSTFLAYL RQVFGIPEPR

TP
Length:402
Mass (Da):46,265
Last modified:September 23, 2008 - v1
Checksum:i87785B369B2D9AA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001050 Genomic DNA Translation: ACF29514.1

Genome annotation databases

EnsemblBacteriaiACF29514; ACF29514; NGK_0833
KEGGingk:NGK_0833

Similar proteinsi

Entry informationi

Entry nameiPNCB_NEIG2
AccessioniPrimary (citable) accession number: B4RL23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome