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B4RKE4 (B4RKE4_NEIG2) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Spermidine synthase HAMAP-Rule MF_00198
EC=2.5.1.16 HAMAP-Rule MF_00198
Alternative name(s):
Putrescine aminopropyltransferase HAMAP-Rule MF_00198
SPDSY HAMAP-Rule MF_00198
Gene names
Name:speE HAMAP-Rule MF_00198
Ordered Locus Names:NGK_0604 EMBL ACF29295.1
OrganismNeisseria gonorrhoeae (strain NCCP11945) [Complete proteome] [HAMAP] EMBL ACF29295.1
Taxonomic identifier521006 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria ›

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor By similarity. HAMAP-Rule MF_00198

Catalytic activity

S-adenosylmethioninamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine. HAMAP-Rule MF_00198

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. HAMAP-Rule MF_00198

Subunit structure

Homodimer and homotetramer By similarity. HAMAP-Rule MF_00198

Sequence similarities

Belongs to the spermidine/spermine synthase family. HAMAP-Rule MF_00198

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region126 – 1272S-adenosylmethioninamine binding By similarity HAMAP-Rule MF_00198

Sites

Active site1441Proton acceptor By similarity HAMAP-Rule MF_00198
Binding site981S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site1471Putrescine By similarity HAMAP-Rule MF_00198

Sequences

Sequence LengthMass (Da)Tools
B4RKE4 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 17ED724B11774181

FASTA26329,782
        10         20         30         40         50         60 
MARHPYRRLR PAKSGFPEVG ISEEGNIRSL HLGSDTVQSS MNLDRPSELV LSYSRAMMGW 

        70         80         90        100        110        120 
LLFAERLPQH ITQIGLGGGS FARWTDTYLP DTRQTAVDIN PQVIAIARNL FELPFEGGKF 

       130        140        150        160        170        180 
EIIEADGAEY IKVFRHNTDI ILVDGFDGEQ IIDTLVEEPF FRDCRNALSS DGIFVTNWWS 

       190        200        210        220        230        240 
GDKRYQRFIE RLLSVFEGRV LELPAESHGN VAVMAFQSSP KEQNIDKLKK RADKLSNAYG 

       250        260 
LDFHRMLAGL KASNPNNGKH FHL

« Hide

References

[1]"Complete genome sequence of Neisseria gonorrhoeae NCCP11945."
Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.
J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCCP11945 EMBL ACF29295.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001050 Genomic DNA. Translation: ACF29295.1.
RefSeqYP_002001229.1. NC_011035.1.

3D structure databases

ProteinModelPortalB4RKE4.
ModBaseSearch...

Protein-protein interaction databases

STRING521006.NGK_0604.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACF29295; ACF29295; NGK_0604.
GeneID6449038.
KEGGngk:NGK_0604.
PATRIC20339562. VBINeiGon87511_0656.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0421.
HOGENOMHOG000263005.
KOK00797.
OMAYHRHYWE.
ProtClustDBPRK04457.

Enzyme and pathway databases

BioCycNGON521006:GJ73-618-MONOMER.
UniPathwayUPA00248; UER00314.

Family and domain databases

HAMAPMF_00198. Spermidine_synth.
InterProIPR001045. Spermidine/spermine_synthase.
[Graphical view]
PfamPF01564. Spermine_synth. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4RKE4_NEIG2
AccessionPrimary (citable) accession number: B4RKE4
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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