B4RJY3 (B4RJY3_NEIG2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Threonine--tRNA ligase HAMAP MF_00184
EC=6.1.1.3 HAMAP MF_00184

Alternative name(s):
Threonyl-tRNA synthetase HAMAP MF_00184

Gene names

Name:	thrS HAMAP MF_00184
Ordered Locus Names:	NGK_0443

Organism

Neisseria gonorrhoeae (strain NCCP11945) [Complete proteome] [HAMAP]

Taxonomic identifier

521006 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	648 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). HAMAP MF_00184
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00184
Subunit structure	Homodimer By similarity. HAMAP MF_00184
Subcellular location	Cytoplasm By similarity HAMAP MF_00184.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family. HAMAP MF_00184 RuleBase RU003746

Ontologies

Keywords
Biological process	Protein biosynthesis HAMAP MF_00184
Cellular component	Cytoplasm HAMAP MF_00184
Ligand	ATP-binding HAMAP MF_00184 Metal-binding HAMAP MF_00184 Nucleotide-binding Zinc HAMAP MF_00184
Molecular function	Aminoacyl-tRNA synthetase HAMAP MF_00184 EMBL ACF29134.1 Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP threonine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4RJY3 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: F4E37B37ADC6F3FF	FASTA	648	74,075
	10 20 30 40 50 60 MPLFFNLSER LMLNITLPDC SVRQYESPVT VAQIAASIGA GLAKAAVAGK VNGKLVDACD 70 80 90 100 110 120 PIVEDSAVQI ITPKDQEGIE IIRHSCAHLV GHAVKQLYPN AKMVIGPVIE EGFYYDIATE 130 140 150 160 170 180 KPFTPEDVAA IEARMKELIA QDYDVVKIMT PRAEAIKIFQ ERGEEYKLRL IEDMPEVEAM 190 200 210 220 230 240 GIYHHQEYVD MCRGPHVPNT RFLKNFKLTK LAGAYWRGDS NNEMLQRIYG TAWATKDELK 250 260 270 280 290 300 DYIQRIEEAE KRDHRKLGKQ LDLFHLQDEA PGMVFWHPKG WALWQTIEQH MRKELNAAGY 310 320 330 340 350 360 KEVKTPQIMD KTFWEKSGHW DNYKDNMFVT SSEKREYAVK PMNCPGHVQI FNNGLRSYRD 370 380 390 400 410 420 LPMRLAEFGS CHRNEPSGAL HGLMRVRGFV QDDAHIFCTE DQIVSEARAF NELLVRIYKQ 430 440 450 460 470 480 FGFHDVSVRL SLRPEKRAGS DDVWDKAEQG LREALTACGV EWGELPGEGA FYGPKIEYHV 490 500 510 520 530 540 KDALGRSWQC GTLQLDFVLP ERLDAEYVTE NNDRARPVML HRAILGSLER FVGILIENHA 550 560 570 580 590 600 GSFPLWLAPV QMVIMNITEN QADYCREVAA KLQAAGFRAE LDLRNEKIGY KIRDNSQYRF 610 620 630 640 PYQIVIGDKE KQENKVAVRR KAEDLGSLDL DDFIAQLQQE ITDALVNH

References

[1]	"Complete genome sequence of Neisseria gonorrhoeae NCCP11945." Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K. J. Bacteriol. 190:6035-6036(2008) [PubMed: 18586945] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001050 Genomic DNA. Translation: ACF29134.1.
RefSeq	YP_002001068.1. NC_011035.1.
3D structure databases
ProteinModelPortal	B4RJY3.
ModBase	Search...
Protein-protein interaction databases
STRING	B4RJY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000006784; EBNEIP00000006556; EBNEIG00000006784.
GeneID	6447447.
GenomeReviews	Gene locus NGK_0443 in contig CP001050_GR.
KEGG	ngk:NGK_0443.
PATRIC	20339226. VBINeiGon87511_0489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000021120.
HOGENOM	HBG352811.
OMA	VGSDALW.
ProtClustDB	PRK00413.
Family and domain databases
HAMAP	MF_00184. Thr_tRNA_synth. [Tree]
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-dom. IPR006195. aa-tRNA-synth_II. IPR004154. Anticodon-bd. IPR012675. Beta-grasp_ferredoxin-type. IPR004095. TGS. IPR012676. TGS-like. IPR002320. Thr-tRNA-synth_IIa. IPR018163. Thr/Ala-tRNA-synth_IIc_edit. IPR012947. tRNA_SAD. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit. G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
KO	K01868.
Pfam	PF03129. HGTP_anticodon. 1 hit. PF02824. TGS. 1 hit. PF00587. tRNA-synt_2b. 1 hit. PF07973. tRNA_SAD. 1 hit. [Graphical view]
PRINTS	PR01047. TRNASYNTHTHR.
SMART	SM00863. tRNA_SAD. 1 hit. [Graphical view]
SUPFAM	SSF52954. Anticodon_bd. 1 hit. SSF81271. TGS-like. 1 hit. SSF55186. Thr/Ala-tRNA-synth_IIc_edit. 1 hit.
TIGRFAMs	TIGR00418. ThrS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4RJY3_NEIG2

Accession

Primary (citable) accession number: B4RJY3

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)