ID APAH_NEIG2 Reviewed; 276 AA. AC B4RJQ3; DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 1. DT 27-MAR-2024, entry version 82. DE RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical {ECO:0000255|HAMAP-Rule:MF_00199}; DE EC=3.6.1.41 {ECO:0000255|HAMAP-Rule:MF_00199}; DE AltName: Full=Ap4A hydrolase {ECO:0000255|HAMAP-Rule:MF_00199}; DE AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase {ECO:0000255|HAMAP-Rule:MF_00199}; DE AltName: Full=Diadenosine tetraphosphatase {ECO:0000255|HAMAP-Rule:MF_00199}; GN Name=apaH {ECO:0000255|HAMAP-Rule:MF_00199}; GN OrderedLocusNames=NGK_0363; OS Neisseria gonorrhoeae (strain NCCP11945). OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae; OC Neisseria. OX NCBI_TaxID=521006; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCCP11945; RX PubMed=18586945; DOI=10.1128/jb.00566-08; RA Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.; RT "Complete genome sequence of Neisseria gonorrhoeae NCCP11945."; RL J. Bacteriol. 190:6035-6036(2008). CC -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield CC ADP. {ECO:0000255|HAMAP-Rule:MF_00199}. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 CC H(+); Xref=Rhea:RHEA:24252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:58141, ChEBI:CHEBI:456216; EC=3.6.1.41; CC Evidence={ECO:0000255|HAMAP-Rule:MF_00199}; CC -!- SIMILARITY: Belongs to the Ap4A hydrolase family. {ECO:0000255|HAMAP- CC Rule:MF_00199}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001050; ACF29056.1; -; Genomic_DNA. DR RefSeq; WP_003687564.1; NC_011035.1. DR AlphaFoldDB; B4RJQ3; -. DR SMR; B4RJQ3; -. DR GeneID; 66752567; -. DR KEGG; ngk:NGK_0363; -. DR HOGENOM; CLU_056184_2_0_4; -. DR Proteomes; UP000002564; Chromosome. DR GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:UniProtKB-UniRule. DR CDD; cd07422; MPP_ApaH; 1. DR Gene3D; 3.60.21.10; -; 1. DR HAMAP; MF_00199; ApaH; 1. DR InterPro; IPR004617; ApaH. DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH. DR InterPro; IPR029052; Metallo-depent_PP-like. DR NCBIfam; TIGR00668; apaH; 1. DR PANTHER; PTHR42850:SF11; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [SYMMETRICAL]; 1. DR PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1. DR Pfam; PF00149; Metallophos; 1. DR PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1. DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1. PE 3: Inferred from homology; KW Hydrolase. FT CHAIN 1..276 FT /note="Bis(5'-nucleosyl)-tetraphosphatase, symmetrical" FT /id="PRO_1000099327" SQ SEQUENCE 276 AA; 30879 MW; 4163840FC6E16CF6 CRC64; MAHYAIGDIQ GCFDELTALL GKIGFNHGTD TLWLTGDIVN RGPKSLETLQ FCIRHENSVQ IVLGNHDLYL LAVGCGEGAL KRSDTIEPIL KHPDGGKMLD WLRAQPLLIR EGGRVMIHAG ILPQWRIAKA ESLAGEAEAE LRGKKYVKFF SKMYGNKPAA WDEGLEGYAR LRFIVNAFTR MRALTFKNEL DFDYKSTVKK MPPYLRPWFK APDRQNLDHT IIFGHWSSLG YTNADNVISL DTGALWGGQL TAVNLETEEI TQVQAAGGID WKSFAK //