B4RJQ3 (APAH_NEIG2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	NGK_0363

Organism

Neisseria gonorrhoeae (strain NCCP11945) [Complete proteome] [HAMAP]

Taxonomic identifier

521006 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria gonorrhoeae

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP-Rule MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP-Rule MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP-Rule MF_00199		PRO_1000099327

Sequences

	Sequence		Length	Mass (Da)
	B4RJQ3 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 4163840FC6E16CF6	FASTA	276	30,879
	10 20 30 40 50 60 MAHYAIGDIQ GCFDELTALL GKIGFNHGTD TLWLTGDIVN RGPKSLETLQ FCIRHENSVQ 70 80 90 100 110 120 IVLGNHDLYL LAVGCGEGAL KRSDTIEPIL KHPDGGKMLD WLRAQPLLIR EGGRVMIHAG 130 140 150 160 170 180 ILPQWRIAKA ESLAGEAEAE LRGKKYVKFF SKMYGNKPAA WDEGLEGYAR LRFIVNAFTR 190 200 210 220 230 240 MRALTFKNEL DFDYKSTVKK MPPYLRPWFK APDRQNLDHT IIFGHWSSLG YTNADNVISL 250 260 270 DTGALWGGQL TAVNLETEEI TQVQAAGGID WKSFAK

References

[1]	"Complete genome sequence of Neisseria gonorrhoeae NCCP11945." Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K. J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCCP11945.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001050 Genomic DNA. Translation: ACF29056.1.
RefSeq	YP_002000988.1. NC_011035.1.
3D structure databases
ProteinModelPortal	B4RJQ3.
ModBase	Search...
Protein-protein interaction databases
STRING	521006.NGK_0363.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACF29056; ACF29056; NGK_0363.
GeneID	6449651.
KEGG	ngk:NGK_0363.
PATRIC	20339054. VBINeiGon87511_0405.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HOG000251871.
KO	K01525.
OMA	WLRHQPL.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	NGON521006:GJ73-373-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH.
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_NEIG2

Accession

Primary (citable) accession number: B4RJQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program