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B4RJQ3

- APAH_NEIG2

UniProt

B4RJQ3 - APAH_NEIG2

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Protein
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
Gene
apaH, NGK_0363
Organism
Neisseria gonorrhoeae (strain NCCP11945)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

  1. bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciNGON521006:GJ73-373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene namesi
Name:apaH
Ordered Locus Names:NGK_0363
OrganismiNeisseria gonorrhoeae (strain NCCP11945)
Taxonomic identifieri521006 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002564: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation
PRO_1000099327Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521006.NGK_0363.

Structurei

3D structure databases

ProteinModelPortaliB4RJQ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251871.
KOiK01525.
OMAiTIVCGHW.
OrthoDBiEOG66B3WP.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RJQ3-1 [UniParc]FASTAAdd to Basket

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MAHYAIGDIQ GCFDELTALL GKIGFNHGTD TLWLTGDIVN RGPKSLETLQ    50
FCIRHENSVQ IVLGNHDLYL LAVGCGEGAL KRSDTIEPIL KHPDGGKMLD 100
WLRAQPLLIR EGGRVMIHAG ILPQWRIAKA ESLAGEAEAE LRGKKYVKFF 150
SKMYGNKPAA WDEGLEGYAR LRFIVNAFTR MRALTFKNEL DFDYKSTVKK 200
MPPYLRPWFK APDRQNLDHT IIFGHWSSLG YTNADNVISL DTGALWGGQL 250
TAVNLETEEI TQVQAAGGID WKSFAK 276
Length:276
Mass (Da):30,879
Last modified:September 23, 2008 - v1
Checksum:i4163840FC6E16CF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001050 Genomic DNA. Translation: ACF29056.1.
RefSeqiYP_002000988.1. NC_011035.1.

Genome annotation databases

EnsemblBacteriaiACF29056; ACF29056; NGK_0363.
GeneIDi6449651.
KEGGingk:NGK_0363.
PATRICi20339054. VBINeiGon87511_0405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001050 Genomic DNA. Translation: ACF29056.1 .
RefSeqi YP_002000988.1. NC_011035.1.

3D structure databases

ProteinModelPortali B4RJQ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521006.NGK_0363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF29056 ; ACF29056 ; NGK_0363 .
GeneIDi 6449651.
KEGGi ngk:NGK_0363.
PATRICi 20339054. VBINeiGon87511_0405.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000251871.
KOi K01525.
OMAi TIVCGHW.
OrthoDBi EOG66B3WP.

Enzyme and pathway databases

BioCyci NGON521006:GJ73-373-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 2 hits.
HAMAPi MF_00199. ApaH.
InterProi IPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
TIGRFAMsi TIGR00668. apaH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Neisseria gonorrhoeae NCCP11945."
    Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.
    J. Bacteriol. 190:6035-6036(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCCP11945.

Entry informationi

Entry nameiAPAH_NEIG2
AccessioniPrimary (citable) accession number: B4RJQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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