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B4RF16

- GCSPA_PHEZH

UniProt

B4RF16 - GCSPA_PHEZH

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, PHZ_c0590
Organism
Phenylobacterium zucineum (strain HLK1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciPZUC450851:GHUG-595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:PHZ_c0590
OrganismiPhenylobacterium zucineum (strain HLK1)
Taxonomic identifieri450851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaePhenylobacterium
ProteomesiUP000001868: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000132485Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi450851.PHZ_c0590.

Structurei

3D structure databases

ProteinModelPortaliB4RF16.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiFFHEAVL.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B4RF16-1 [UniParc]FASTAAdd to Basket

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MRYLPLTPED RAQMLGVIGA PDVDALFADV PAAARNPAIG LAPHAGELEV    50
ERELSGLAAL NRAAGAGPFF CGAGAYRHHV PATVDHIIQR SEFLTSYTPY 100
QPEIAQGTLQ VLFEFQTQVA RLTGLDVANA SMYDGSTACA EAVMMAQRVT 150
RREKAILSGG LHPHYAATTQ TIAHAEGMEI VRQPAAIDAE AAVIEAIDAE 200
TACVVVQTPN VFGVVTDVSK IAEAAHAKGA LLIVVTTEAV AYGLLKSPGE 250
MGADIAVAEG QSIGNALNYG GPYVGLFACR EKFVRNMPGR LCGETVDAEG 300
RRGYVLTLST REQHIRREKA TSNICTNSGL CALAFSIHLS LLGGKGLSQL 350
ARVNHARARE LKAAVEAAGL EVLTPRFFNE IAVRTKGPAA DLVERLLADG 400
VVAGVPFSRL DPGAGLDDVL LLCATETTTS DDIAALKDAL AR 442
Length:442
Mass (Da):46,516
Last modified:September 23, 2008 - v1
Checksum:iBFC3D498A23BBC66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000747 Genomic DNA. Translation: ACG77004.1.
RefSeqiWP_012521152.1. NC_011144.1.
YP_002129433.1. NC_011144.1.

Genome annotation databases

EnsemblBacteriaiACG77004; ACG77004; PHZ_c0590.
GeneIDi6790081.
KEGGipzu:PHZ_c0590.
PATRICi22923806. VBIPheZuc44517_0997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000747 Genomic DNA. Translation: ACG77004.1 .
RefSeqi WP_012521152.1. NC_011144.1.
YP_002129433.1. NC_011144.1.

3D structure databases

ProteinModelPortali B4RF16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 450851.PHZ_c0590.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG77004 ; ACG77004 ; PHZ_c0590 .
GeneIDi 6790081.
KEGGi pzu:PHZ_c0590.
PATRICi 22923806. VBIPheZuc44517_0997.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi FFHEAVL.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci PZUC450851:GHUG-595-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562."
    Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.
    BMC Genomics 9:386-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HLK1.

Entry informationi

Entry nameiGCSPA_PHEZH
AccessioniPrimary (citable) accession number: B4RF16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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