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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Phenylobacterium zucineum (strain HLK1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPZUC450851:GHUG-246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotationSAAS annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:PHZ_c0242Imported
OrganismiPhenylobacterium zucineum (strain HLK1)Imported
Taxonomic identifieri450851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaePhenylobacterium
Proteomesi
  • UP000001868 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi450851.PHZ_c0242.

Structurei

3D structure databases

ProteinModelPortaliB4RD52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 172145Nudix hydrolaseInterPro annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 8422Nudix boxUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotationSAAS annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066722.
KOiK08311.
OMAiQNAWQFP.
OrthoDBiPOG091H0392.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4RD52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGERGGAEGL SAGPRLGAHG PEMTDLSRYR PNVGVVLFHP DGRVWLGRRA
60 70 80 90 100
GAAPPYNWQF PQGGVDDGEE LEAAARRELA EETGAVSIAY LGRTDGWIVY
110 120 130 140 150
DFPEGMGGPK AWRGFKGQRQ VWFAFRFDGE ESEFDLAAHH EPEFEEWRWG
160 170 180
YLAEAPDLVV PFKRQAYEQV ARAFAPLAAR HGGG
Length:184
Mass (Da):20,360
Last modified:September 23, 2008 - v1
Checksum:i7878C94A02F49C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000747 Genomic DNA. Translation: ACG76656.1.

Genome annotation databases

EnsemblBacteriaiACG76656; ACG76656; PHZ_c0242.
KEGGipzu:PHZ_c0242.
PATRICi22923038. VBIPheZuc44517_0614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000747 Genomic DNA. Translation: ACG76656.1.

3D structure databases

ProteinModelPortaliB4RD52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi450851.PHZ_c0242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACG76656; ACG76656; PHZ_c0242.
KEGGipzu:PHZ_c0242.
PATRICi22923038. VBIPheZuc44517_0614.

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066722.
KOiK08311.
OMAiQNAWQFP.
OrthoDBiPOG091H0392.

Enzyme and pathway databases

BioCyciPZUC450851:GHUG-246-MONOMER.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4RD52_PHEZH
AccessioniPrimary (citable) accession number: B4RD52
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.